ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Executive function and attention are preserved in older surgically menopausal monkeys receiving estrogen or estrogen plus progesterone.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- Estrogen Replacement Improves Verbal Memory and Executive Control in Oligomenorrheic/Amenorrheic Athletes in a Randomized Controlled Trial.The Journal of clinical psychiatry · 2017Trial
- Impact of atomoxetine on subjective attention and memory difficulties in perimenopausal and postmenopausal women.Menopause (New York, N.Y.) · 2011Trial
- The aged female rhesus macaque as a translational model for human menopause and hormone therapy.Hormones and behavior · 2024Article
- Effect of short-term androgen supplementation on cognitive performance in older male rhesus macaques.Neurobiology of aging · 2023Article
- Cognitive development from infancy to young adulthood in common marmosets (Callithrix jacchus): Effect of age, sex, and hormones on learning and affective state.Developmental psychobiology · 2023Article
- Sex differences in cognitive flexibility are driven by the estrous cycle and stress-dependent.Frontiers in behavioral neuroscience · 2022Article
- Xiao-Yao-San Formula Improves Cognitive Ability by Protecting the Hippocampal Neurons in Ovariectomized Rats.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Age-related decline in cognitive flexibility in female chimpanzees.Neurobiology of aging · 2018Article
- Timing of cyclic estradiol treatment differentially affects cognition in aged female rhesus monkeys.Behavioral neuroscience · 2018Article
- Ovarian hormones, sleep and cognition across the adult female lifespan: An integrated perspective.Frontiers in neuroendocrinology · 2017Review
- Socially Housed Female Macaques: a Translational Model for the Interaction of Chronic Stress and Estrogen in Aging.Current psychiatry reports · 2017Review
- Estrogen enhances hippocampal gray-matter volume in young and older postmenopausal women: a prospective dose-response study.Neurobiology of aging · 2017Article
- An exploratory study of host polymorphisms in genes that clinically characterize breast cancer tumors and pretreatment cognitive performance in breast cancer survivors.Breast cancer (Dove Medical Press) · 2017Article
- Estrogen Effects on Cognitive and Synaptic Health Over the Lifecourse.Physiological reviews · 2015Review
- Why primate models matter.American journal of primatology · 2014Review
- Oestradiol modulation of cognition in adult female marmosets (Callithrix jacchus).Journal of neuroendocrinology · 2014Article
- Estrogen and the prefrontal cortex: towards a new understanding of estrogen's effects on executive functions in the menopause transition.Human brain mapping · 2014Review
- Multiple clinically relevant hormone therapy regimens fail to improve cognitive function in aged ovariectomized rhesus monkeys.Neurobiology of aging · 2013Article
- Estrogen regulation of spine density and excitatory synapses in rat prefrontal and somatosensory cerebral cortex.Steroids · 2013Article
- Continuously delivered ovarian steroids do not alter dendritic spine density or morphology in macaque dorsolateral prefrontal cortical neurons.Neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Animal models of menopause have been used to further define the cognitive processes that respond to hormone therapy and to investigate parameters that may influence the cognitive effects of estrogen. Many investigations in animals have focused on memory; however, the effects of hormone therapy on executive function and attention processes have not been well studied. Thus, the purpose of this set of investigations was to assess the effects of estrogen therapy alone or with progesterone on executive and attention processes in middle-aged ovariectomized monkeys. Monkeys were preoperatively trained on a modified version of the Wisconsin card sort task and on a visual cued reaction time task. Hormone therapy was initiated at the time of ovariectomy and cognitive function was reassessed at 2, 12, and 24 weeks postoperatively. Relative to monkeys receiving either of the estrogen therapies, monkeys receiving placebo were impaired in their ability to shift a cognitive set in the Wisconsin card sort task and were impaired in shifting visuospatial attention in the visual cued reaction time task. Our findings are consistent with clinical studies that indicate that hormone therapy can improve executive function and attention processes in postmenopausal women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.