ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Neocortical networks entrain neuronal circuits in cerebellar cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed, 122 citations in OpenAlex.
- Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026Review
- Global and local nature of cortical slow waves.iScience · 2025Article
- Human-specific features of the cerebellum and ZP2-regulated synapse development.bioRxiv : the preprint server for biology · 2025Article
- Cerebellar basket cell filtering of Purkinje cell responses elicited by low frequency parallel fibre transmission.Scientific reports · 2025Article
- The cerebellum converts input data into a hyper low-resolution granule cell code with spatial dimensions: a hypothesis.Royal Society open science · 2025Article
- A multi-layer mean-field model of the cerebellum embedding microstructure and population-specific dynamics.PLoS computational biology · 2023Article
- Neocortical and cerebellar malformations affect flurothyl-induced seizures in female C57BL/6J mice.Frontiers in neuroscience · 2023Article
- Delta Oscillations Coordinate Intracerebellar and Cerebello-Hippocampal Network Dynamics during Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Effects of continuous positive airway pressure treatment on sleep architecture in adults with obstructive sleep apnea and type 2 diabetes.Frontiers in human neuroscience · 2022Article
- Mice Lacking Cerebellar Cortex and Related Structures Show a Decrease in Slow-Wave Activity With Normal Non-REM Sleep Amount and Sleep Homeostasis.Frontiers in behavioral neuroscience · 2022Article
- Medium spiny neurons activity reveals the discrete segregation of mouse dorsal striatum.eLife · 2021Article
- Stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum.Scientific reports · 2021Article
- Cerebellar Coordination of Neuronal Communication in Cerebral Cortex.Frontiers in systems neuroscience · 2021Article
- Article
- Multiple signals evoked by unisensory stimulation converge onto cerebellar granule and Purkinje cells in mice.Communications biology · 2020Article
- Resistance, vulnerability and resilience: A review of the cognitive cerebellum in aging and neurodegenerative diseases.Neurobiology of learning and memory · 2020Review
- Cerebellar D1DR-expressing neurons modulate the frontal cortex during timing tasks.Neurobiology of learning and memory · 2020Article
- Optimization of Efficient Neuron Models With Realistic Firing Dynamics. The Case of the Cerebellar Granule Cell.Frontiers in cellular neuroscience · 2020Article
- Cerebellar Cortex 4-12 Hz Oscillations and Unit Phase Relation in the Awake Rat.Frontiers in systems neuroscience · 2020Article
- Perspective on the Multiple Pathways to Changing Brain States.Frontiers in systems neuroscience · 2020Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Activity in neocortex is often characterized by synchronized oscillations of neurons and networks, resulting in the generation of a local field potential (LFP) and electroencephalogram. Do the neuronal networks of the cerebellum also generate synchronized oscillations and are they under the influence of those in the neocortex? Here we show that, in the absence of any overt external stimulus, the cerebellar cortex generates a slow oscillation that is correlated with that of the neocortex. Disruption of the neocortical slow oscillation abolishes the cerebellar slow oscillation, whereas blocking cerebellar activity has no overt effect on the neocortex. We provide evidence that the cerebellar slow oscillation results in part from the activation of granule, Golgi, and Purkinje neurons. In particular, we show that granule and Golgi cells discharge trains of single spikes, and Purkinje cells generate complex spikes, during the "up" state of the slow oscillation. Purkinje cell simple spiking is weakly related to the cerebellar and neocortical slow oscillation in a minority of cells. Our results indicate that the cerebellum generates rhythmic network activity that can be recorded as an LFP in the anesthetized animal, which is driven by synchronized oscillations of the neocortex. Furthermore, we show that correlations between neocortical and cerebellar LFPs persist in the awake animal, indicating that neocortical circuits modulate cerebellar neurons in a similar manner in natural behavioral states. Thus, the projection neurons of the neocortex collectively exert a driving and modulatory influence on cerebellar network activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.