ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
PKC differentially translocates during spaced and massed training in Aplysia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed.
- The massed-spaced learning effect in non-neural human cells.Nature communications · 2024Article
- Network motifs exhibiting a differential response to spaced and massed inputs.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Isolation of the differential effects of chronic and acute stress in a manner that is not confounded by stress severity.Neurobiology of stress · 2024Article
- Quantitative description of the interactions among kinase cascades underlying long-term plasticity of Aplysia sensory neurons.Scientific reports · 2021Article
- Making a Lecture Stick: the Effect of Spaced Instruction on Knowledge Retention in Medical Education.Medical science educator · 2020Article
- Neurotropic and modulatory effects of insulin-like growth factor II in Aplysia.Scientific reports · 2019Article
- The Interval Between VNS-Tone Pairings Determines the Extent of Cortical Map Plasticity.Neuroscience · 2018Article
- Intermittent apnea elicits inactivity-induced phrenic motor facilitation via a retinoic acid- and protein synthesis-dependent pathway.Journal of neurophysiology · 2017Article
- Sustained Hypoxia Elicits Competing Spinal Mechanisms of Phrenic Motor Facilitation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Transforming growth factor β recruits persistent MAPK signaling to regulate long-term memory consolidation in Aplysia californica.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- The right time to learn: mechanisms and optimization of spaced learning.Nature reviews. Neuroscience · 2016Review
- Histone deacetylase inhibition facilitates massed pattern-induced synaptic plasticity and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Bidirectional regulation of eEF2 phosphorylation controls synaptic plasticity by decoding neuronal activity patterns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Decline in the Recovery from Synaptic Depression in Heavier Aplysia Results from Decreased Serotonin-Induced Novel PKC Activation.PloS one · 2015Article
- Activity-dependent inhibitory gating in molecular signaling cascades induces a novel form of intermediate-term synaptic facilitation in Aplysia californica.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Pattern and predictability in memory formation: from molecular mechanisms to clinical relevance.Neurobiology of learning and memory · 2013Review
- Protein phosphatase-dependent circadian regulation of intermediate-term associative memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Massed training-induced intermediate-term operant memory in aplysia requires protein synthesis and multiple persistent kinase cascades.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Molecular determinants of the spacing effect.Neural plasticity · 2012Review
- The rates of protein synthesis and degradation account for the differential response of neurons to spaced and massed training protocols.PLoS computational biology · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Learning is highly regulated by the pattern of training. In Aplysia, an important organism for the development of cellular and molecular models of learning, spaced versus massed application of the same stimulus leads to different forms of memory. A critical molecular step underlying memory is the serotonin (5HT)-mediated activation of the novel PKC Apl II. Here, we demonstrate that activation of PKC Apl II is highly sensitive to the pattern of 5HT application. Spaced applications downregulate PKC translocation through PKA signaling, whereas massed applications lead to persistent translocation of PKC. Differential regulation of PKC translocation is mediated by competing feedback mechanisms that act through protein synthesis. These studies elucidate a fundamental molecular difference between spaced and massed training protocols.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.