ArticleMolecular biology of the cell2009
Transcriptional Suppression by Transient Recruitment of ARIP4 to Sumoylated nuclear receptor Ad4BP/SF-1.
Article in Molecular biology of the cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- R-loop resolution by ARIP4 helicase promotes androgen-mediated transcription induction.Science advances · 2024Article
- RAD54L2 counters TOP2-DNA adducts to promote genome stability.Science advances · 2023Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Impact of GTF2H1 and RAD54L2 polymorphisms on the risk of lung cancer in the Chinese Han population.BMC cancer · 2022Article
- Possible Mechanisms for Maintenance and Regression of Corpus Luteum Through the Ubiquitin-Proteasome and Autophagy System Regulated by Transcriptional Factors.Frontiers in endocrinology · 2019Review
- Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids.Communications biology · 2018Article
- A Protein Preparation Method for the High-throughput Identification of Proteins Interacting with a Nuclear Cofactor Using LC-MS/MS Analysis.Journal of visualized experiments : JoVE · 2017Article
- Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation.Scientific reports · 2015Article
- Scavenger receptors mediate the role of SUMO and Ftz-f1 in Drosophila steroidogenesis.PLoS genetics · 2013Article
- Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search.The Journal of biological chemistry · 2012Article
- Dynamic SUMOylation is linked to the activity cycles of androgen receptor in the cell nucleus.Molecular and cellular biology · 2012Article
- Strategies to Identify Recognition Signals and Targets of SUMOylation.Biochemistry research international · 2012Article
- Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development.Developmental cell · 2011Article
- Coactivation of SF-1-mediated transcription of steroidogenic enzymes by Ubc9 and PIAS1.Endocrinology · 2011Article
- ATP-dependent chromatin remodeling: genetics, genomics and mechanisms.Cell research · 2011Review
- Exportin 4 interacts with Sox9 through the HMG Box and inhibits the DNA binding of Sox9.PloS one · 2011Article
- Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The small ubiquitin-like modifier SUMO conjugates transcription factors and suppresses their respective activation of target genes. Although various SUMO-modified transcription factors have been isolated, mechanisms whereby sumoylated-substrates modulate transcription remain unknown. Here, we purified ARIP4 (AR interacting protein 4, a Rad54 family member and a SNF2 chromatin remodeling factor), which interacts with sumoylated Ad4BP/SF-1 through two SUMO-interacting motifs and one Ad4BP/SF-1-binding region. Remarkably, ARIP4 also interacts selectively with other sumoylated nuclear receptors including LRH-1, AR, and GR. Interestingly, the ATPase activity of ARIP4 was stimulated in the presence of sumoylated Ad4BP/SF-1 and the Ad4BP/SF-1-binding site containing double-stranded DNA. ChIP assays and siRNA studies strongly suggested that ARIP4 temporally suppresses Ad4BP/SF-1-mediated transcription through its transient recruitment to target genes. These findings suggest that ARIP4 may be a cofactor that modulates SUMO-mediated fine-tuning of transcriptional suppression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.