Evidence map›Paper›PMID 19692544›Full record

ArticleThe Journal of general virology2009

Multiple novel astrovirus species in human stool.

A Kapoor, L Li, J Victoria, B Oderinde, C Mason, P Pandey, S Z Zaidi, E Delwart

Open access · greenAbstract read
In one paragraph

Article in The Journal of general virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 243 citations in OpenAlex.

  1. Porcine astrovirus: a review.Archives of virology · 2026
    Review
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  17. Structure of the divergent human astrovirus MLB capsid spike.Structure (London, England : 1993) · 2022
    Article
  18. Gut virome in early life: origins and implications.Current opinion in virology · 2022
    Review
  19. Article
  20. Article

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 5 countries.

A KapoorDepartment of Laboratory Medicine, University of California San Francisco, and Blood Systems Research Institute, San Francisco, CA, USA.
L LiDepartment of Laboratory Medicine, University of California San Francisco, and Blood Systems Research Institute, San Francisco, CA, USA.
J VictoriaDepartment of Laboratory Medicine, University of California San Francisco, and Blood Systems Research Institute, San Francisco, CA, USA.
B OderindeWHO National Polio Laboratory, University of Maiduguri Teaching Hospital, Borno State, Nigeria.
C MasonDepartment of Enteric Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
P PandeyCIWEC Clinic Travel Medicine Center, Kathmandu, Nepal.
S Z ZaidiDepartment of Virology, National Institute of Health, Islamabad, Pakistan.
E DelwartDepartment of Laboratory Medicine, University of California San Francisco, and Blood Systems Research Institute, San Francisco, CA, USA.
Blood Systems Research Institute · USArmed Forces Research Institute of Medical Science · THCivil Service Hospital · NPNational Institute of Health · PKUniversity of California, San Francisco · USUniversity of Maiduguri · NG

Funding

Metagenomic analysis of the human viromeR01HL083254 · NHLBI · VITALANT · PI DELWART, ERIC L · 2007 to 2010
$1.6M
NHLBI NIH HHS R01 HL083254NHLBI NIH HHS R01HL083254
6 · The paper itself

Abstract

Diarrhoea remains a significant cause of morbidity and mortality in developing countries where numerous cases remain without identified aetiology. Astroviruses are a recently identified cause of animal gastroenteritis which currently includes two species suspected of causing human diarrhoea. Using pan-astrovirus RT-PCR, we analysed human stool samples from different continents for astrovirus-related RNA sequences. We identified variants of the two known human astrovirus species plus, based on genetic distance criteria, three novel astrovirus species all distantly related to mink and ovine astroviruses, which we provisionally named HMOAstV species A-C. The complete genome of species A displayed all the conserved characteristics of mammalian astroviruses. Each of the now three groups of astroviruses found in human stool (HAstV, AstV-MLB and HMOAstV) were more closely related to animal astroviruses than to each other, indicating that human astroviruses may periodically emerge from zoonotic transmissions. Based on the pathogenic impact of their closest phylogenetic relatives in animals, further investigations of the role of HMOAstV, so far detected in Nigeria, Nepal and Pakistan, in human gastroenteritis are warranted.

Indexed as

AnimalsAstroviridae InfectionsDiarrheaFecesGastroenteritisHumansMamastrovirusMolecular Sequence DataPhylogenySequence Analysis, DNASpecies Specificity

Identifiers

PMID19692544
PMCPMC2796194
OpenAlexW2114025285

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.