Evidence map›Paper›PMID 19692530›Full record

Trial reportThe Journal of nutrition2009

Tart cherry juice decreases oxidative stress in healthy older men and women.

Tinna Traustadóttir, Sean S Davies, Anthoney A Stock, Yali Su, Christopher B Heward, L Jackson Roberts, S Mitchell Harman

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 3 syntheses or guidelines pooled it, 149 citations in OpenAlex.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tinna TraustadóttirKronos Longevity Research Institute, Phoenix, AZ, USA. tinna.traustadottir@kronosinstitute.org
Sean S Davies
Anthoney A Stock
Yali Su
Christopher B Heward
L Jackson Roberts
S Mitchell Harman
Kronos Longevity Research Institute · USVanderbilt University · US

Funding

Structural Identification of Prostaglandin ConjugatesR37GM042056 · NIGMS · VANDERBILT UNIVERSITY · PI ROBERTS, II, L JACKSON · 2001 to 2010
$6.5M
STRUCTURAL IDENTIFICATION OF PROSTAGLANDIN CONJUGATESR01GM042056 · NIGMS · VANDERBILT UNIVERSITY · PI ROBERTS, L JACKSON · 1989 to 2000
$441k
NIGMS NIH HHS GM42056
6 · The paper itself

Abstract

Compared with young adults, older adults have significantly impaired capacities to resist oxidative damage when faced with acute stress such as ischemia/reperfusion. This impairment likely contributes to increased morbidity and mortality in older adults in response to acute trauma, infections, and the susceptibility to diseases such as atherosclerosis, cancer, diabetes, and Alzheimer's disease. Consumption of foods high in polyphenols, particularly anthocyanins, have been associated with improved health, but the mechanisms contributing to these salutary effects remain to be fully established. This study tested the hypothesis that consumption of tart cherry juice containing high levels of anthocyanins improves the capacity of older adults to resist oxidative damage during acute oxidative stress. In a double-blind, placebo-controlled, crossover design, 12 volunteers [6 men and 6 women; age 69 +/- 4 y (61-75 y)] consumed in random order either tart cherry juice or placebo (240 mL twice daily for 14 d) separated by a 4-wk washout period. The capacity to resist oxidative damage was measured as the changes in plasma F(2)-isoprostane levels in response to forearm ischemia-reperfusion (I/R) before and after each treatment. The tart cherry juice intervention reduced the I/R-induced F(2)-isoprostane response (P < 0.05), whereas placebo had no significant effect. The tart cherry juice intervention also reduced basal urinary excretion of oxidized nucleic acids (8-hydroxy-2'-deoxyguanosine, 8-hydroxyguanosine) (P < 0.05) but not urinary excretion of isoprostanes. These data suggest that consumption of tart cherry juice improves antioxidant defenses in vivo in older adults as shown by an increased capacity to constrain an oxidative challenge and reduced oxidative damage to nucleic acids.

Indexed as

BeveragesPrunusAgedCross-Over StudiesFatty Acids, UnsaturatedFemaleFruitHumansIsoprostanesMaleMiddle AgedNucleic AcidsOxidative StressFatty Acids, UnsaturatedIsoprostanesNucleic Acids

Identifiers

PMID19692530
PMCPMC3151016
OpenAlexW2144810186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.