Trial reportThe Journal of nutrition2009
Feeding rapidly stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing translation initiation.
Trial report in The Journal of nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Long-term leucine supplementation increases body weight in goats by controlling appetite and muscle protein synthesis under protein-restricted conditions.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Review: Nutritional regulation of muscle growth in neonatal swine.Animal : an international journal of animal bioscience · 2023Review
- Preterm birth alters the feeding-induced activation of Akt signaling in the muscle of neonatal piglets.Pediatric research · 2023Article
- Differential effect of two dietary protein sources on time course response of muscle anabolic signaling pathways in normal and insulin dysregulated horses.Frontiers in veterinary science · 2022Article
- Glutamine supplementation stimulates cell proliferation in skeletal muscle and cultivated myogenic cells of low birth weight piglets.Scientific reports · 2021Article
- Prematurity blunts the insulin- and amino acid-induced stimulation of translation initiation and protein synthesis in skeletal muscle of neonatal pigs.American journal of physiology. Endocrinology and metabolism · 2021Article
- Intermittent Bolus Feeding Enhances Organ Growth More Than Continuous Feeding in a Neonatal Piglet Model.Current developments in nutrition · 2020Article
- The distribution of eukaryotic initiation factor 4E after bouts of resistance exercise is altered by shortening of recovery periods.The journal of physiological sciences : JPS · 2020Article
- Leucine Supplementation Does Not Restore Diminished Skeletal Muscle Satellite Cell Abundance and Myonuclear Accretion When Protein Intake Is Limiting in Neonatal Pigs.The Journal of nutrition · 2020Article
- The influence of dietary leucine above recommendations and fixed ratios to isoleucine and valine on muscle protein synthesis and degradation pathways in broilers.Poultry science · 2019Article
- Regulation of Muscle Growth in Early Postnatal Life in a Swine Model.Annual review of animal biosciences · 2019Review
- Downregulated Translation Initiation Signaling Predisposes Low-Birth-Weight Neonatal Pigs to Slower Rates of Muscle Protein Synthesis.Frontiers in physiology · 2017Article
- Mechanisms of protein balance in skeletal muscle.Domestic animal endocrinology · 2016Review
- Pulsatile delivery of a leucine supplement during long-term continuous enteral feeding enhances lean growth in term neonatal pigs.American journal of physiology. Endocrinology and metabolism · 2016Article
- Feeding critically ill patients the right 'whey': thinking outside of the box. A personal view.Annals of intensive care · 2015Article
- Leucine is a major regulator of muscle protein synthesis in neonates.Amino acids · 2015Review
- Bolus vs. continuous feeding to optimize anabolism in neonates.Current opinion in clinical nutrition and metabolic care · 2015Review
- Viscera and muscle protein synthesis in neonatal pigs is increased more by intermittent bolus than by continuous feeding.Pediatric research · 2013Article
- The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb.American journal of physiology. Endocrinology and metabolism · 2013Article
- Enteral leucine supplementation increases protein synthesis in skeletal and cardiac muscles and visceral tissues of neonatal pigs through mTORC1-dependent pathways.Pediatric research · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Food consumption increases protein synthesis in most tissues by promoting translation initiation, and in the neonate, this increase is greatest in skeletal muscle. In this study, we aimed to identify the currently unknown time course of changes in the rate of protein synthesis and the activation of factors involved in translation in neonatal muscle after a meal. After overnight food deprivation, 36 5- to 7-d-old piglets were administered a nutritionally complete bolus i.g. meal and were killed immediately before or 30, 60, 90, 120, or 240 min later. The increase in skeletal muscle protein synthesis peaked 30 min after the meal and this was sustained through 120 min, returning to baseline thereafter. The relative proportion of polysomes to nonpolysomes was higher only after 30 min. Protein kinase B phosphorylation peaked 30 min after feeding and returned to baseline by 90 min. The phosphorylation of mammalian target of rapamycin, eukaryotic initiation factor (eIF) 4E binding protein (4E-BP1), ribosomal protein S6, and eIF4G was increased within 30 min of feeding and persisted through 120 min, but all had returned to baseline by 240 min. The association of 4E-BP1.eIF4E was reduced and eIF4E.eIF4G increased 30 min after receiving a meal, remaining so for 120 min, before returning to baseline at 240 min. Thus, in neonates, food consumption rapidly increased skeletal muscle protein synthesis by enhancing translation initiation and this increase was sustained for at least 120 min after the meal but returned to baseline by 240 min after the feeding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.