ArticleJournal of neurophysiology2009
Balance of inhibitory and excitatory synaptic activity is altered in fast-spiking interneurons in experimental cortical dysplasia.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 52 citations in OpenAlex.
- Loss of postnatal Arx transcriptional activity in parvalbumin interneurons reveals non-cell autonomous disturbances in CA1 pyramidal cells.Neuroscience · 2024Article
- Developmental depression-to-facilitation shift controls excitation-inhibition balance.Communications biology · 2022Article
- Drug-resistant focal epilepsy in children is associated with increased modal controllability of the whole brain and epileptogenic regions.Communications biology · 2022Article
- Islet1 Precursors Contribute to Mature Interneuron Subtypes in Mouse Neocortex.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- PostnataliScience · 2021Article
- Immunohistological Examination of AKT Isoforms in the Brain: Cell-Type Specificity That May Underlie AKT's Role in Complex Brain Disorders and Neurological Disease.Cerebral cortex communications · 2021Article
- GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions.The Journal of clinical investigation · 2020Article
- Maternal Immune Activation Affects Hippocampal Excitatory and Inhibitory Synaptic Transmission in Offspring From an Early Developmental Period to Adulthood.Frontiers in cellular neuroscience · 2020Article
- Morphine Differentially Alters the Synaptic and Intrinsic Properties of D1R- and D2R-Expressing Medium Spiny Neurons in the Nucleus Accumbens.Frontiers in synaptic neuroscience · 2019Article
- Mild Traumatic Brain Injury Induces Structural and Functional Disconnection of Local Neocortical Inhibitory Networks via Parvalbumin Interneuron Diffuse Axonal Injury.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Neurophysiology and Regulation of the Balance Between Excitation and Inhibition in Neocortical Circuits.Biological psychiatry · 2017Review
- HCN Channel Modulation of Synaptic Integration in GABAergic Interneurons in Malformed Rat Neocortex.Frontiers in cellular neuroscience · 2017Article
- Continuous spike-waves during slow-wave sleep in a mouse model of focal cortical dysplasia.Epilepsia · 2016Article
- Genetic animal models of malformations of cortical development and epilepsy.Journal of neuroscience methods · 2016Review
- Involvement of cortical fast-spiking parvalbumin-positive basket cells in epilepsy.Progress in brain research · 2016Review
- Article
- Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.Frontiers in cellular neuroscience · 2014Article
- Targeted disruption of layer 4 during development increases GABAA receptor neurotransmission in the neocortex.Journal of neurophysiology · 2014Article
- Stem cells as a potential therapy for epilepsy.Experimental neurology · 2013Review
- Cortical dysplasia: a possible substrate for brain tumors.Future oncology (London, England) · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cortical dysplasia (CD) is a common cause of intractable epilepsy in children and adults. We have studied rats irradiated in utero as a model of CD to better understand mechanisms that underlie dysplasia-associated epilepsy. Prior studies have shown a reduction in the number of cortical interneurons and in the frequency of inhibitory postsynaptic currents (IPSCs) in pyramidal cells in this model. They have also shown a reduced frequency of spontaneous and miniature excitatory postsynaptic currents (EPSCs) in the surviving cortical interneurons. However, the inhibitory synaptic contacts were not examined in that study. The current experiments were performed to assess inhibitory synaptic activity in fast-spiking (FS) interneurons in irradiated rats and controls and the balance of excitatory and inhibitory synaptic activity in these cells. Whole cell recordings were obtained from layer IV FS cells in controls and comparable FS cells in irradiated rats. The frequency of spontaneous and miniature IPSCs was reduced in dysplastic cortex, but the amplitude of these currents was unchanged. Stimulus-evoked IPSCs showed short-term depression in control and short-term facilitation in dysplastic cortex. Simultaneous recording of spontaneous EPSCs and IPSCs showed a shift in the ratio of excitation-to-inhibition in favor of inhibition in FS cells from dysplastic cortex. The same shift toward inhibition was seen when miniature EPSCs and IPSCs were examined. These results show that FS cells in dysplastic cortex have a relative lack of excitatory drive. This may result in an important class of inhibitory cells that are less able to perform their normal function especially in periods of increased excitatory activity.
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