ArticleJournal of virology2009
VP5* rearranges when rotavirus uncoats.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Comparative analysis of NSP5/VP2-induced viroplasm-like structures in rotavirus species A to J.Journal of virology · 2025Article
- TREM-1 Interacts with Rotavirus Proteins and Drives Inflammatory Responses: A Combined Experimental and Computational Approach.Pathogens (Basel, Switzerland) · 2025Article
- Structural determinants of rotavirus proteolytic activation.PLoS pathogens · 2025Article
- Review
- Rotavirus Spike Protein VP4 Mediates Viroplasm Assembly by Association to Actin Filaments.Journal of virology · 2022Article
- Using Species a Rotavirus Reverse Genetics to Engineer Chimeric Viruses Expressing SARS-CoV-2 Spike Epitopes.Journal of virology · 2022Article
- Control of Capsid Transformations during Reovirus Entry.Viruses · 2021Review
- Histo-blood group antigens as divergent factors of groups A and C rotaviruses circulating in humans and different animal species.Emerging microbes & infections · 2020Article
- Visualization of Calcium Ion Loss from Rotavirus during Cell Entry.Journal of virology · 2018Article
- Most rotavirus strains require the cation-independent mannose-6-phosphate receptor, sortilin-1, and cathepsins to enter cells.Virus research · 2018Article
- Inflammatory and oxidative stress in rotavirus infection.World journal of virology · 2016Review
- Atomic model of a nonenveloped virus reveals pH sensors for a coordinated process of cell entry.Nature structural & molecular biology · 2016Article
- Structural correlates of rotavirus cell entry.PLoS pathogens · 2014Article
- New insights into rotavirus entry machinery: stabilization of rotavirus spike conformation is independent of trypsin cleavage.PLoS pathogens · 2014Article
- Rotaviruses reach late endosomes and require the cation-dependent mannose-6-phosphate receptor and the activity of cathepsin proteases to enter the cell.Journal of virology · 2014Article
- The molecular biology of Bluetongue virus replication.Virus research · 2014Review
- Genome-wide RNAi screen reveals a role for the ESCRT complex in rotavirus cell entry.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Mutations in the rotavirus spike protein VP4 reduce trypsin sensitivity but not viral spread.The Journal of general virology · 2013Article
- Interactions among capsid proteins orchestrate rotavirus particle functions.Current opinion in virology · 2012Review
- Rhesus rotavirus trafficking during entry into MA104 cells is restricted to the early endosome compartment.Journal of virology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Trypsin primes rotavirus for efficient infectivity by cleaving the spike protein, VP4, into VP8* and VP5*. A recombinant VP5* fragment has a trimeric, folded-back structure. Comparison of this structure with virion spikes suggests that a rearrangement, analogous to those of enveloped virus fusion proteins, may mediate membrane penetration by rotavirus during entry. To detect this inferred rearrangement of virion-associated authentic VP5*, we raised conformation-specific monoclonal antibodies against the recombinant VP5* fragment in its putative post-membrane penetration conformation. Using one of these antibodies, we demonstrate that rotavirus uncoating triggers a conformational change in the cleaved VP4 spike to yield rearranged VP5*.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.