ArticleJournal of virology2009
Human uterine natural killer cells but not blood natural killer cells inhibit human immunodeficiency virus type 1 infection by secretion of CXCL12.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Uterine natural killer cell-mediated immune imbalance impairs uterine vascular remodeling and contributes to adverse pregnancy outcomes in dengue virus-infected mice.Microbiology spectrum · 2026Article
- Innate Immune Protection Against HIV in the Female Genital Tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Review
- Placenta - A Competent, But Not Infallible, Antiviral and Antiparasitic Barrier.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Maternal natural killer cells at the intersection between reproduction and mucosal immunity.Mucosal immunology · 2021Review
- The impact of aging on innate and adaptive immunity in the human female genital tract.Aging cell · 2021Review
- HIV Pathogenesis in the Human Female Reproductive Tract.Current HIV/AIDS reports · 2021Review
- The Importance of Regulation in Natural Immunity to HIV.Vaccines · 2021Review
- Estradiol-regulated innate antiviral responses of human endometrial stromal fibroblasts.American journal of reproductive immunology (New York, N.Y. : 1989) · 2018Article
- Menopausal status influences the expression of programmed death (PD)-1 and its ligand PD-L1 on immune cells from the human female reproductive tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2016Article
- Phenotype and functions of conventional and non-conventional NK cells.Current opinion in immunology · 2016Review
- The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy.Cellular & molecular immunology · 2016Article
- Article
- Innate immunity in the vagina (Part II): Anti-HIV activity and antiviral content of human vaginal secretions.American journal of reproductive immunology (New York, N.Y. : 1989) · 2014Article
- The up side of decidual natural killer cells: new developments in immunology of pregnancy.Immunology · 2014Review
- Distribution of immune cells in the human cervix and implications for HIV transmission.American journal of reproductive immunology (New York, N.Y. : 1989) · 2014Article
- Pathogenesis and prevention of placental and transplacental porcine reproductive and respiratory syndrome virus infection.Veterinary research · 2013Review
- Human cytomegalovirus infection elicits new decidual natural killer cell effector functions.PLoS pathogens · 2013Article
- In vitro anti-HIV-1 activity in cervicovaginal secretions from pregnant and nonpregnant women.American journal of obstetrics and gynecology · 2012Article
- Natural killer (NK) and NK-like cells at mucosal epithelia: Mediators of anti-microbial defense and maintenance of tissue integrity.European journal of microbiology & immunology · 2011Review
- Decidual soluble factors participate in the control of HIV-1 infection at the maternofetal interface.Retrovirology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Natural killer (NK) cells derived from the human female reproductive tract (FRT) are phenotypically and functionally distinct from those obtained from peripheral blood. Because the FRT is a primary site of human immunodeficiency virus type 1 (HIV-1) infection in women, we determined whether soluble factors secreted by uterine-derived NK (uNK) cells inhibit HIV-1 infection. Clonal populations of uNK cells were activated with interleukin-12 (IL-12) and IL-15, and conditioned media (CM) from these cultures evaluated for their ability to inhibit infection of cells by HIV-1(IIIB), HIV-1(NL4.3), and HIV-1(HC4) (X4-tropic) or HIV-1(BaL) (R5-tropic) viruses. We found that soluble factors secreted by activated uNK cells significantly inhibited X4-tropic virus infection of TZM-bl cells, peripheral blood mononuclear cells, and primary human endometrial cells, but not infection by HIV-1(BaL). In contrast, CM from peripheral blood NK (bNK) cells did not inhibit HIV-1 infection of cells. Analysis of factors secreted from uNK clones with anti-HIV-1 activity demonstrated significantly higher levels of CXCL12 compared to uNK clones without this activity, and the HIV inhibitory activity was neutralized by antibodies to CXCL12. Collectively, these data demonstrate that human uNK cells release chemokines with anti-HIV-1 activity for X4-tropic strains and this suggest that these chemokines may contribute to the inhibition of X4-tropic strain transmission across mucosal tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.