ArticleBMC neuroscience2009
Diacylglycerol kinase beta promotes dendritic outgrowth and spine maturation in developing hippocampal neurons.
Article in BMC neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 47 citations in OpenAlex.
- Integration of human and mouse single-cell transcriptomes of the developing cerebellum nominates cells-of-origin for group 3 and 4 medulloblastoma.BMC cancer · 2026Article
- DGKs in lipid signaling and disease intervention: structural basis, pathological mechanisms, and emerging therapeutic strategies.Cellular & molecular biology letters · 2025Review
- Disrupted hypothalamic transcriptomics and proteomics in a mouse model of type 2 diabetes exposed to recurrent hypoglycaemia.Diabetologia · 2024Article
- RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth.Biomolecules · 2021Article
- Roles of DGKs in neurons: Postsynaptic functions?Advances in biological regulation · 2020Review
- Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid inDisease models & mechanisms · 2018Article
- Inhibition of the Ras/Raf/ERK1/2 Signaling Pathway Restores Cultured Spinal Cord-Injured Neuronal Migration, Adhesion, and Dendritic Spine Development.Neurochemical research · 2016Article
- Genetic basis of a cognitive complexity metric.PloS one · 2015Article
- Diacylglycerol, phosphatidic acid, and their metabolic enzymes in synaptic vesicle recycling.Advances in biological regulation · 2015Review
- Differential distribution of phospholipase C beta isoforms and diaglycerol kinase-beta in rodents cerebella corroborates the division of unipolar brush cells into two major subtypes.Brain structure & function · 2014Article
- Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe.Molecular psychiatry · 2012Article
- Article
- IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation.Journal of neuroinflammation · 2011Article
- Dual regulation of RA-RhoGAP activity by phosphatidic acid and Rap1 during neurite outgrowth.The Journal of biological chemistry · 2011Article
- Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities.PloS one · 2010Article
- TNFRSF11B computational development network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients.Journal of inflammation (London, England) · 2010Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol to phosphatidic acid and comprises multiple isozymes of distinct properties. Of DGKs, mRNA signal for DGKbeta is strongly detected in the striatum, and one of the transcripts derived from the human DGKbeta locus is annotated in GenBank as being differentially expressed in bipolar disorder patients. Recently, we have reported that DGKbeta is expressed in medium spiny neurons of the striatum and is highly concentrated at the perisynapse of dendritic spines. However, it remains elusive how DGKbeta is implicated in pathophysiological role in neurons at the cellular level.
resultsIn the present study, we investigated the expression and subcellular localization of DGKbeta in the hippocampus, together with its functional implication using transfected hippocampal neurons. DGKbeta is expressed not only in projection neurons but also in interneurons and is concentrated at perisynaptic sites of asymmetrical synapses. Overexpression of wild-type DGKbeta promotes dendrite outgrowth at 7 d in vitro (DIV) and spine maturation at 14 DIV in transfected hippocampal neurons, although its kinase-dead mutant has no effect.
conclusionIn the hippocampus, DGKbeta is expressed in both projection neurons and interneurons and is accumulated at the perisynapse of dendritic spines in asymmetrical synapses. Transfection experiments suggest that DGKbeta may be involved in the molecular machineries of dendrite outgrowth and spinogenesis through its kinase activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.