Evidence map›Paper›PMID 19691834›Full record

Trial reportLipids in health and disease2009

Effect of eicosapentaenoic and docosahexaenoic acid on resting and exercise-induced inflammatory and oxidative stress biomarkers: a randomized, placebo controlled, cross-over study.

Richard J Bloomer, Douglas E Larson, Kelsey H Fisher-Wellman, Andrew J Galpin, Brian K Schilling

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Lipids in health and disease, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02610270 (Erythrocyte Omega-3 Fatty Acid Content in Elite Athletes in Response to Omega-3 Supplementation), which is not on this map. Cited by 52 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 6 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02610270 early_phase1completednot on this mapstarted 2014, after this paper: background citation

Erythrocyte Omega-3 Fatty Acid Content in Elite Athletes in Response to Omega-3 Supplementation: A Dose-Response

TypeinterventionalSponsorCentre d'Alt RendimentRan2014 to 2015Enrolled24ConditionsHealthyArms2 Gums, 3 Gums
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 6 syntheses or guidelines pooled it, 139 citations in OpenAlex.

  1. Effects of LCNutrients · 2026
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  19. The Role of Omega-3 Polyunsaturated Fatty Acids on Sarcopenia and Aging Muscle.International journal of environmental research and public health · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Richard J BloomerCardiorespiratory/Metabolic Laboratory, Department of Health and Sport Sciences, The University of Memphis, Memphis, TN 38152, USA. rbloomer@memphis.edu
Douglas E Larson
Kelsey H Fisher-Wellman
Andrew J Galpin
Brian K Schilling
University of Memphis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of the present investigation was to determine the effects of EPA/DHA supplementation on resting and exercise-induced inflammation and oxidative stress in exercise-trained men. Fourteen men supplemented with 2224 mg EPA+2208 mg DHA and a placebo for 6 weeks in a random order, double blind cross-over design (with an 8 week washout) prior to performing a 60 minute treadmill climb using a weighted pack. Blood was collected pre and post exercise and analyzed for a variety of oxidative stress and inflammatory biomarkers. Blood lactate, muscle soreness, and creatine kinase activity were also measured.

resultsTreatment with EPA/DHA resulted in a significant increase in blood levels of both EPA (18 +/- 2 micromol x L(-1) vs. 143 +/- 23 micromol x L(-1); p < 0.0001) and DHA (67 +/- 4 micromol x L(-1) vs. 157 +/- 13 micromol x L(-1); p < 0.0001), while no differences were noted for placebo. Resting levels of CRP and TNF-alpha were lower with EPA/DHA compared to placebo (p < 0.05). Resting oxidative stress markers were not different (p > 0.05). There was a mild increase in oxidative stress in response to exercise (XO and H2O2) (p < 0.05). No interaction effects were noted. However, a condition effect was noted for CRP and TNF-alpha, with lower values with the EPA/DHA condition.

conclusionEPA/DHA supplementation increases blood levels of these fatty acids and results in decreased resting levels of inflammatory biomarkers in exercise-trained men, but does not appear necessary for exercise-induced attenuation in either inflammation or oxidative stress. This may be due to the finding that trained men exhibit a minimal increase in both inflammation and oxidative stress in response to moderate duration (60 minute) aerobic exercise.

Indexed as

ExerciseAdultAnalysis of VarianceBiomarkersBody Mass IndexC-Reactive ProteinCross-Over StudiesDietary SupplementsDocosahexaenoic AcidsDouble-Blind MethodEicosapentaenoic AcidEnergy MetabolismHeart RateHumansInflammationMaleBiomarkersC-Reactive ProteinDocosahexaenoic AcidsEicosapentaenoic AcidTumor Necrosis Factor-alpha

Identifiers

PMID19691834
PMCPMC2735747
OpenAlexW2160398757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.