ArticleGenome medicine2009
Lithium: a key to the genetics of bipolar disorder.
Article in Genome medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study.Translational psychiatry · 2024Article
- Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study.Research square · 2023Article
- Immunoglobulin genes expressed in lymphoblastoid cell lines discern and predict lithium response in bipolar disorder patients.Molecular psychiatry · 2023Article
- Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder.BMC psychiatry · 2022Article
- Translational relevance of forward genetic screens in animal models for the study of psychiatric disease.Neuroscience and biobehavioral reviews · 2022Review
- Predicted Cellular and Molecular Actions of Lithium in the Treatment of Bipolar Disorder: An In Silico Study.CNS drugs · 2020Article
- Exploring lithium's transcriptional mechanisms of action in bipolar disorder: a multi-step study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- The Role of Pharmacogenomics in Bipolar Disorder: Moving Towards Precision Medicine.Molecular diagnosis & therapy · 2018Review
- PIKfyve inhibition increases exosome release and induces secretory autophagy.Cellular and molecular life sciences : CMLS · 2016Article
- Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder.Molecular psychiatry · 2016Article
- Circadian Clock Dysfunction and Psychiatric Disease: Could Fruit Flies have a Say?Frontiers in neurology · 2015Review
- Response to lithium in bipolar disorder: clinical and genetic findings.ACS chemical neuroscience · 2014Review
- Genetic influences on response to mood stabilizers in bipolar disorder: current status of knowledge.CNS drugs · 2013Review
- Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report.PloS one · 2013Article
- Interaction networks of lithium and valproate molecular targets reveal a striking enrichment of apoptosis functional clusters and neurotrophin signaling.The pharmacogenomics journal · 2012Article
- Response to treatment in bipolar disorder.Current opinion in psychiatry · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the 1950s, lithium salts have been the main line of treatment for bipolar disorder (BD), both as a prophylactic and as an episodic treatment agent. Like many psychiatric conditions, BD is genetically and phenotypically heterogeneous, but evidence suggests that individuals who respond well to lithium treatment have more homogeneous clinical and molecular profiles. Response to lithium seems to cluster in families and can be used as a predictor for recurrence of BD symptoms. While molecular studies have provided important information about possible genes involved in BD predisposition or in lithium response, neither the mechanism of action of this drug nor the genetic profile of bipolar disorder is, as yet, completely understood.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.