ArticleCritical reviews in food science and nutrition2009
The Key Events Dose-Response Framework: its potential for application to foodborne pathogenic microorganisms.
Article in Critical reviews in food science and nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- Efficacy of Cannabidiol in Reducing Virulence ofInternational journal of molecular sciences · 2026Article
- Deliberating the scientific evidence base for influenza transmission to raw milk consumers.Risk analysis : an official publication of the Society for Risk Analysis · 2025Review
- Health risk assessment of Staphylococcus aureus and Salmonella from the consumption of street foods in Ethiopia.BMC infectious diseases · 2025Article
- Review
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- Competitive growth kinetics of Campylobacter jejuni, Escherichia coli O157:H7 and Listeria monocytogenes with enteric microflora in a small-intestine model.Journal of applied microbiology · 2022Article
- A New Dose-Response Model for Estimating the Infection Probability of Campylobacter jejuni Based on the Key Events Dose-Response Framework.Applied and environmental microbiology · 2021Article
- Evaluation of Strain Variability in Inactivation of Campylobacter jejuni in Simulated Gastric Fluid by Using Hierarchical Bayesian Modeling.Applied and environmental microbiology · 2021Article
- Modeling Invasion of Campylobacter jejuni into Human Small Intestinal Epithelial-Like Cells by Bayesian Inference.Applied and environmental microbiology · 2020Article
- Dose-response and transmission: the nexus between reservoir hosts, environment and recipient hosts.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Advancing risk assessment: mechanistic dose-response modelling ofRoyal Society open science · 2018Article
- Diffusible substances from lactic acid bacterial cultures exert strong inhibitory effects on Listeria monocytogenes and Salmonella enterica serovar enteritidis in a co-culture model.BMC microbiology · 2017Article
- Predictive Modeling for Estimation of Bacterial Behavior from Farm to Table.Food safety (Tokyo, Japan) · 2016Review
- Making pathogens sociable: the [corrected] emergence of high relatedness through limited host invasibility.The ISME journal · 2015Article
- Dose-response algorithms for water-borne Pseudomonas aeruginosa folliculitis.Epidemiology and infection · 2015Article
- Bacterial Cooperation Causes Systematic Errors in Pathogen Risk Assessment due to the Failure of the Independent Action Hypothesis.PLoS pathogens · 2015Article
- A proof-of-concept model for the identification of the key events in the infection process with specific reference to Pseudomonas aeruginosa in corneal infections.Infection ecology & epidemiology · 2015Article
- Modeling of pathogen survival during simulated gastric digestion.Applied and environmental microbiology · 2011Article
- The Key Events Dose-Response Framework: a cross-disciplinary mode-of-action based approach to examining dose-response and thresholds.Critical reviews in food science and nutrition · 2009Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Key Events Dose-Response Framework (KEDRF) is an analytical approach that facilitates the use of currently available data to gain insight regarding dose-response relationships. The use of the KEDRF also helps identify critical knowledge gaps that once filled, will reduce reliance on assumptions. The present study considers how the KEDRF might be applied to pathogenic microorganisms, using fetal listeriosis resulting from maternal ingestion of food contaminated with L. monocytogenes as an initial example. Major biological events along the pathway between food ingestion and the endpoint of concern are systematically considered with regard to dose (i.e., number of organisms), pathogen factors (e.g., virulence), and protective host mechanisms (e.g., immune response or other homeostatic mechanisms). It is concluded that the KEDRF provides a useful structure for systematically evaluating the complex array of host and pathogen factors that influence the dose-response relationship. In particular, the KEDRF supports efforts to specify and quantify the sources of variability, a prerequisite to strengthening the scientific basis for food safety decision making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.