ArticleEuropean journal of applied physiology2009
Proteolysis activation and proteome alterations in murine skeletal muscle submitted to 1 week of hindlimb suspension.
Article in European journal of applied physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Effects of Moderate Exercise Training on Cancer-Induced Muscle Wasting.Healthcare (Basel, Switzerland) · 2023Article
- Characterization of Contractile Proteins from Skeletal Muscle Using Gel-Based Top-Down Proteomics.Proteomes · 2019Review
- Does altered protein metabolism interfere with postmortem degradation analysis for PMI estimation?International journal of legal medicine · 2018Article
- Muscle-specific and age-related changes in protein synthesis and protein degradation in response to hindlimb unloading in rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Review
- CrossTalk opposing view: The dominant mechanism causing disuse muscle atrophy is proteolysis.The Journal of physiology · 2014Article
- Intricate effects of primary motor neuronopathy on contractile proteins and metabolic muscle enzymes as revealed by label-free mass spectrometry.Bioscience reports · 2014Article
- Disuse-induced muscle wasting.The international journal of biochemistry & cell biology · 2013Review
- Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Pathobiochemical changes in diabetic skeletal muscle as revealed by mass-spectrometry-based proteomics.Journal of nutrition and metabolism · 2012Article
- Proteomic profiling of skeletal muscle plasticity.Muscles, ligaments and tendons journal · 2011Article
- Skeletal muscle proteomics: current approaches, technical challenges and emerging techniques.Skeletal muscle · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the temporal involvement of different proteolytic systems and muscle proteome changes during experimental disuse atrophy (up to 1 week hindlimb suspension, HS) in murine gastrocnemius muscle. The results showed that proteolysis, cytoprotection mechanisms and signs of cellular infiltration occurred very early. After 1 day of HS, signals of lysosomal activation, rather than programmed cell death (apoptosis), seem to trigger protein breakdown in the whole skeletal muscle. Moreover, the ubiquitin-proteasome pathway remained elevated later whereas all other proteolytic parameters returned to control values when atrophy was fully established. Using proteomics, evidence is provided for metabolic alterations toward glycolysis and for cytoskeleton remodelling suggestive of reduced capacity for force generation. Overall, our data highlight an early and coordinated time-dependent activation of proteolysis, which explains the global proteome alterations observed in gastrocnemius under atrophic conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.