ArticleClinics (Sao Paulo, Brazil)2009
Comorbidities in severe asthma: frequency of rhinitis, nasal polyposis, gastroesophageal reflux disease, vocal cord dysfunction and bronchiectasis.
Article in Clinics (Sao Paulo, Brazil), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Coexistence of COPD or asthma in patients with bronchiectasis: a systematic review and meta-analysis.BMC pulmonary medicine · 2026Pooled it
- Family Physicians' Awareness of the Burden of Oral Corticosteroids in Asthma Patients.Acta medica academica · 2024Observational
- Trends in Anaphylaxis Hospitalizations among Adults in Spain and Their Relationship with Asthma-Analysis of Hospital Discharge data from 2016 to 2021.Healthcare (Basel, Switzerland) · 2023Article
- High Level of Blood Eosinophils and Localization of Bronchiectasis in Patients with Severe Asthma: A Pilot Study.Journal of clinical medicine · 2023Article
- Can Leukotriene Receptor Antagonist Therapy Improve the Control of Patients with Severe Asthma on Biological Therapy and Coexisting Bronchiectasis? A Pilot Study.Journal of clinical medicine · 2022Article
- Long-Term Prognosis of Asthma-Bronchiectasis Overlapped Patients: A Nationwide Population-Based Cohort Study.Allergy, asthma & immunology research · 2021Article
- Low-Cost Joystick for Pediatric Respiratory Exercises.Journal of medical systems · 2020Article
- Is bronchiectasis really a disease?European respiratory review : an official journal of the European Respiratory Society · 2020Article
- Prevalence of atopy and allergic rhinitis in patients with adult non-cystic fibrosis bronchiectasisTurkish journal of medical sciences · 2019Article
- Immunostimulants in respiratory diseases: focus on Pidotimod.Multidisciplinary respiratory medicine · 2019Review
- Severe uncontrolled asthma with bronchiectasis: a pilot study of an emerging phenotype that responds to mepolizumab.Journal of asthma and allergy · 2019Article
- Factors associated with bronchiectasis in patients with uncontrolled asthma; the NOPES score: a study in 398 patients.Respiratory research · 2018Article
- Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults.European clinical respiratory journal · 2018Review
- Effectiveness of Healthcare Coordination in Patients with Chronic Respiratory Diseases.Advances in experimental medicine and biology · 2018Article
- Asthma referrals: a key component of asthma management that needs to be addressed.Journal of asthma and allergy · 2017Review
- Toward an Understanding of the Pathophysiology of Chronic Laryngitis.Perspectives of the ASHA special interest groups · 2016Article
- United airway disease: current perspectives.Journal of asthma and allergy · 2016Review
- Approach to Patients with Severe Asthma: a Consensus Statement from the Respiratory Care Experts' Input Forum (RC-EIF), Iran.Tanaffos · 2015Review
- A comparison of impulse oscillometry and spirometry values in patients with gastroesophageal reflux disease.Middle East journal of digestive diseases · 2013Article
- Prevalence of bronchiectasis in asthma according to oral steroid requirement: influence of immunoglobulin levels.BioMed research international · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSevere asthma is found in approximately 10% of patients with asthma. Some factors associated with worse asthma control include rhinitis, gastroesophageal reflux disease, vocal cord dysfunction (VCD), nasal polyposis and bronchiectasis. Therefore, we evaluated the prevalence of these illnesses in patients with severe asthma.
methodsWe conducted a retrospective analysis of data obtained from electronic medical records of patients with severe asthma between January 2006 and June 2008. Symptoms of rhinitis and gastroesophageal reflux disease were evaluated as well as intolerance to nonsteroidal anti-inflammatory drugs. We evaluated the results of esophagogastroduodenoscopy, videolaryngoscopy and CT scans of the chest in order to confirm gastroesophageal reflux disease, nasal polyposis, vocal cord dysfunction and bronchiectasis.
resultsWe evaluated 245 patients. Rhinitis symptoms were present in 224 patients (91.4%); 18 (7.3%) had intolerance to nonsteroidal anti-inflammatory drugs, and 8 (3.3%) had nasal polyposis. Symptoms of gastroesophageal reflux disease were reported for 173 (70.6%) patients, although the diagnosis of gastroesophageal reflux disease was confirmed based on esophagogastroduodenoscopy or laryngoscopy findings in just 58 (33.6%) patients. Vocal cord dysfunction was suspected in 16 (6.5%) and confirmed through laryngoscopy in 4 (1.6%). The patient records provided CT scans of the chest for 105 patients, and 26 (24.8%) showed bronchiectasis. DISCUSSION: Rhinitis and gastroesophageal reflux disease were the most common comorbidities observed, in addition to bronchiectasis. Therefore, in patients with severe asthma, associated diseases should be investigated as the cause of respiratory symptoms and uncontrolled asthma.
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