Trial reportClinics (Sao Paulo, Brazil)2009
Twenty months of evolution following sympathectomy on patients with palmar hyperhidrosis: sympathectomy at the T3 level is better than at the T2 level.
Trial report in Clinics (Sao Paulo, Brazil), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01118429 (Use of Oxybutynin to Treat Axillary Hyperhidrosis), which is not on this map. Cited by 20 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Oxybutynin to Treat Axillary Hyperhidrosis
Who cites it
20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- T2-sparing vs T2-including sympathectomy for hyperhidrosis: a meta-analysis on compensatory sweating.Journal of cardiothoracic surgery · 2026Pooled it
- Quality of life after thoracic sympathectomy for palmar hyperhidrosis: a meta-analysis.General thoracic and cardiovascular surgery · 2020Pooled it
- Optimal targeting of sympathetic chain levels for treatment of palmar hyperhidrosis: an updated systematic review.Surgical endoscopy · 2017Pooled it
- A systematic review and meta-analysis of T2, T3 or T4, to evaluate the best denervation level for palmar hyperhidrosis.Scientific reports · 2017Pooled it
- Compensatory sweating after restricting or lowering the level of sympathectomy: a systematic review and meta-analysis.Clinics (Sao Paulo, Brazil) · 2015Pooled it
- Objective evaluation of plantar hyperhidrosis after sympathectomy.Clinics (Sao Paulo, Brazil) · 2013Trial
- An alternative to treat palmar hyperhidrosis: use of oxybutynin.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2011Trial
- Systemic effect of sympathectomy in the treatment of localized hyperhidrosis.Updates in surgery · 2026Article
- Quality of life and compensatory hyperhidrosis following thoracoscopic sympathectomy: a retrospective cohort study.Journal of cardiothoracic surgery · 2025Article
- Single-center experience of thoracoscopic sympathectomy for palmar hyperhidrosis with long-term postoperative questionnaire survey.General thoracic and cardiovascular surgery · 2024Article
- Bilateral one-stage single-port sympathicotomy in primary focal hyperhidrosis, a prospective cohort study: treat earlier?Journal of cardiothoracic surgery · 2021Article
- A retrospective cohort study of T3 versus T4 thoracoscopic sympathectomy for primary palmar hyperhidrosis and primary palmar hyperhidrosis with axillary and plantar sweating.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2020Article
- Is there any relationship between quality of life and the level of sympathectomy in primary palmar hyperhidrosis? Single-center experience.General thoracic and cardiovascular surgery · 2020Article
- Can we predict the compensatory hyperhidrosis following a thoracic sympathectomy?Indian journal of thoracic and cardiovascular surgery · 2019Article
- Compensatory hyperhidrosis after different surgeries at the same sympathetic levels: a meta-analysis.Annals of translational medicine · 2018Article
- Comparisons of the clinical outcomes of thoracoscopic sympathetic surgery for palmar hyperhidrosis: R4 sympathicotomy versus R4 sympathetic clipping versus R3 sympathetic clipping.Journal of thoracic disease · 2016Article
- Expanded level of sympathetic chain removal does not increase the incidence or severity of compensatory hyperhidrosis after endoscopic thoracic sympathectomy.The Journal of thoracic and cardiovascular surgery · 2014Article
- Thoracic sympathetic nerve reconstruction for compensatory hyperhidrosis: the Melbourne technique.Annals of translational medicine · 2014Article
- Preservation of α-3 neuronal nicotinic acetylcholine receptor expression in sympathetic ganglia after brain death.Molecular neurobiology · 2012Article
- Is gender a predictive factor for satisfaction among patients undergoing sympathectomy to treat palmar hyperhidrosis?Clinics (Sao Paulo, Brazil) · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare two surgical techniques (denervation levels) for sympathectomy using video-assisted thoracoscopy to treat palmar hyperhidrosis in the long-term.
methodsFrom May 2003 to June 2006, 60 patients with palmar hyperhidrosis were prospectively randomized for video-assisted thoracoscopic sympathectomy at the T2 or T3 ganglion level. They were followed for a mean of 20 months and were evaluated regarding their degree of improvement of palmar hyperhidrosis, incidence and severity of compensatory hyperhidrosis and its evolution over time, and quality of life.
resultsFifty-nine cases presented resolution of the palmar hyperhidrosis. One case of therapeutic failure occurred in the T3 group. Most of the patients presented an improvement in palmar hyperhidrosis, without any difference between the groups. Twenty months later, all patients in both groups presented some degree of compensatory hyperhidrosis but with less severity in the T3 group (p = 0.007). Compensatory hyperhidrosis developed in most patients during the first month after the operation, with incidence and severity that remained stable over time. An improvement in quality of life was seen starting from the first postoperative evaluation but without any difference between the groups. This improvement was maintained until the end of the follow-up.
conclusionBoth techniques were effective for treating palmar hyperhidrosis. The most frequent complication was compensatory hyperhidrosis, which presented stable incidence and severity over the study period. Sympathectomy at the T3 level presented compensatory hyperhidrosis with less severity. Nevertheless, the improvement in quality of life was similar between the groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.