ArticleEuropean journal of human genetics : EJHG2010
Public interest in predictive genetic testing, including direct-to-consumer testing, for susceptibility to major depression: preliminary findings.
Article in European journal of human genetics : EJHG, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic review of consumers' knowledge, attitudes and experiences of primary health professionals' role in genomic medicine.European journal of human genetics : EJHG · 2025Pooled it
- Internet-Based Direct-to-Consumer Genetic Testing: A Systematic Review.Journal of medical Internet research · 2015Pooled it
- Direct-to-consumer genomic testing: systematic review of the literature on user perspectives.European journal of human genetics : EJHG · 2012Pooled it
- Cluster randomized controlled trial of a psycho-educational intervention for people with a family history of depression for use in general practice.BMC psychiatry · 2013Trial
- Ethical considerations in the clinical application of prediction tools for severe mental disorders: perspectives from child and adolescent psychiatrists.Global bioethics = Problemi di bioetica · 2026Article
- Ethical and social issues in prediction of risk of severe mental illness: a scoping review and thematic analysis.BMC psychiatry · 2025Article
- Factors influencing patient decision-making on a multimodal precision medicine algorithm for depression: a qualitative European multicentre study of the PROMPT consortium.Frontiers in psychiatry · 2025Article
- Exploring perceptions of genetic risk and the transmission of substance use disorders.Addiction science & clinical practice · 2024Article
- Returning Genetic Information About Risk for Alcohol Use Disorder to Adolescents: Findings of a Preliminary Qualitative Study of Precision Prevention.AJPM focus · 2024Article
- Attitudes towards genetic testing: The role of genetic literacy, motivated cognition, and socio-demographic characteristics.PloS one · 2023Article
- Beliefs and willingness towards participating in genetic testing for depression in low-income and racial/ethnic minority mothers at-risk.Archives of psychiatric nursing · 2022Article
- Real-World Implementation of Precision Psychiatry: A Systematic Review of Barriers and Facilitators.Brain sciences · 2022Review
- Genetic feedback for psychiatric conditions: Where are we now and where are we going.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2020Review
- "…This Has to Do With My Identity. And I Don't Want to Make it Totally Transparent." Identity Relevance in the Attitudes of Affected People and Laypersons to the Handling of High-Throughput Genomic Data.Frontiers in sociology · 2020Article
- Queensland Consumers' Awareness and Understanding of Clinical Genetics Services.Frontiers in genetics · 2020Article
- Attitudes toward the right to autonomous decision-making in psychiatric genetic testing: Controversial and context-dependent.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Article
- Views of the importance of psychiatric genetic research by potential volunteers from stakeholder groups.Journal of psychiatric research · 2018Article
- Predictive Psychiatric Genetic Testing in Minors: An Exploration of the Non-Medical Benefits.Journal of bioethical inquiry · 2018Article
- Receptiveness to participation in genetic research: A pilot study comparing views of people with depression, diabetes, or no illness.Journal of psychiatric research · 2017Article
- Attitudes to incorporating genomic risk assessments into population screening programs: the importance of purpose, context and deliberation.BMC medical genomics · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The past decade has seen rapid advances in the identification of associations between candidate genes and a range of common multifactorial disorders. This paper evaluates public attitudes towards the complexity of genetic risk prediction in psychiatry involving susceptibility genes, uncertain penetrance and gene-environment interactions on which successful molecular-based mental health interventions will depend. A qualitative approach was taken to enable the exploration of the views of the public. Four structured focus groups were conducted with a total of 36 participants. The majority of participants indicated interest in having a genetic test for susceptibility to major depression, if it was available. Having a family history of mental illness was cited as a major reason. After discussion of perceived positive and negative implications of predictive genetic testing, nine of 24 participants initially interested in having such a test changed their mind. Fear of genetic discrimination and privacy issues predominantly influenced change of attitude. All participants still interested in having a predictive genetic test for risk for depression reported they would only do so through trusted medical professionals. Participants were unanimously against direct-to-consumer genetic testing marketed through the Internet, although some would consider it if there was suitable protection against discrimination. The study highlights the importance of general practitioner and public education about psychiatric genetics, and the availability of appropriate treatment and support services prior to implementation of future predictive genetic testing services.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.