ArticleMolecular systems biology2009
Control and signal processing by transcriptional interference.
Article in Molecular systems biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells.Nature genetics · 2024Article
- Large-Scale Functional Analysis of CRP-Mediated Feed-Forward Loops.International journal of molecular sciences · 2018Article
- Intragenic transcriptional interference regulates the human immune ligand MICA.The EMBO journal · 2018Article
- Article
- Protein Abundance Control by Non-coding Antisense Transcription.Cell reports · 2016Article
- Multiplex Eukaryotic Transcription (In)activation: Timing, Bursting and Cycling of a Ratchet Clock Mechanism.PLoS computational biology · 2015Article
- Suppression of expression between adjacent genes within heterologous modules in yeast.G3 (Bethesda, Md.) · 2014Article
- BCL-3 attenuation of TNFA expression involves an incoherent feed-forward loop regulated by chromatin structure.PloS one · 2013Article
- Promoter sequence determines the relationship between expression level and noise.PLoS biology · 2013Article
- Cooperative binding of transcription factors promotes bimodal gene expression response.PloS one · 2012Article
- Modeling of chromosomal epigenetic silencing processes.Transcription · 2011Article
- Viral-mediated noisy gene expression reveals biphasic E2f1 response to MYC.Molecular cell · 2011Article
- Placing the RPL32 Promoter Upstream of a Second Promoter Results in a Strongly Increased Number of Stably Transfected Mammalian Cell Lines That Display High Protein Expression Levels.Biotechnology research international · 2011Article
- Spatial epigenetic control of mono- and bistable gene expression.PLoS biology · 2010Article
- RNA polymerase mapping during stress responses reveals widespread nonproductive transcription in yeast.Genome biology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A transcriptional activator can suppress gene expression by interfering with transcription initiated by another activator. Transcriptional interference has been increasingly recognized as a regulatory mechanism of gene expression. The signals received by the two antagonistically acting activators are combined by the polymerase trafficking along the DNA. We have designed a dual-control genetic system in yeast to explore this antagonism systematically. Antagonism by an upstream activator bears the hallmarks of competitive inhibition, whereas a downstream activator inhibits gene expression non-competitively. When gene expression is induced weakly, the antagonistic activator can have a positive effect and can even trigger paradoxical activation. Equilibrium and non-equilibrium models of transcription shed light on the mechanism by which interference converts signals, and reveals that self-antagonism of activators imitates the behavior of feed-forward loops. Indeed, a synthetic circuit generates a bell-shaped response, so that the induction of expression is limited to a narrow range of the input signal. The identification of conserved regulatory principles of interference will help to predict the transcriptional response of genes in their genomic context.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.