ArticleBMC neuroscience2009
Integrating microRNA and mRNA expression profiles of neuronal progenitors to identify regulatory networks underlying the onset of cortical neurogenesis.
Article in BMC neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 75 citations in OpenAlex.
- MicroRNA-mediated regulation of proliferation, lineage differentiation, and apoptosis in neural stem cells.RNA biology · 2025Review
- Timing neural development and regeneration.Current opinion in neurobiology · 2025Review
- MicroRNA Nobel Prize: Timely Recognition and High Anticipation of Future Products-A Prospective Analysis.International journal of molecular sciences · 2024Review
- Roles of the miR-155 in Neuroinflammation and Neurological Disorders: A Potent Biological and Therapeutic Target.Cellular and molecular neurobiology · 2023Review
- Evolving features of human cortical development and the emerging roles of non-coding RNAs in neural progenitor cell diversity and function.Cellular and molecular life sciences : CMLS · 2021Article
- MicroRNA Alterations in Induced Pluripotent Stem Cell-Derived Neurons from Bipolar Disorder Patients: Pathways Involved in Neuronal Differentiation, Axon Guidance, and Plasticity.Stem cells and development · 2020Article
- Differential expression of microRNAs in the human fetal left and right cerebral cortex.Molecular biology reports · 2020Article
- Article
- Functional omics analyses reveal only minor effects of microRNAs on human somatic stem cell differentiation.Scientific reports · 2020Article
- The Vast Complexity of the Epigenetic Landscape during Neurodevelopment: An Open Frame to Understanding Brain Function.International journal of molecular sciences · 2018Review
- Transcriptional and Post-Transcriptional Mechanisms of the Development of Neocortical Lamination.Frontiers in neuroanatomy · 2017Review
- MicroRNAs regulate gene plasticity during cold shock in zebrafish larvae.BMC genomics · 2016Article
- Cortical Tubers: Windows into Dysregulation of Epilepsy Risk and Synaptic Signaling Genes by MicroRNAs.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Dynamics of tRNA fragments and their targets in aging mammalian brain.F1000Research · 2016Article
- Integrating genetics and epigenetics in breast cancer: biological insights, experimental, computational methods and therapeutic potential.BMC systems biology · 2015Review
- MicroRNA-mediated regulation of differentiation and trans-differentiation in stem cells.Advanced drug delivery reviews · 2015Review
- The use of microRNAs to modulate redox and immune response to stroke.Antioxidants & redox signaling · 2015Review
- miRGate: a curated database of human, mouse and rat miRNA-mRNA targets.Database : the journal of biological databases and curation · 2015Article
- Transcriptomics and proteomics in stem cell research.Frontiers of medicine · 2014Review
- Ontogeny of small RNA in the regulation of mammalian brain development.BMC genomics · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCortical development is a complex process that includes sequential generation of neuronal progenitors, which proliferate and migrate to form the stratified layers of the developing cortex. To identify the individual microRNAs (miRNAs) and mRNAs that may regulate the genetic network guiding the earliest phase of cortical development, the expression profiles of rat neuronal progenitors obtained at embryonic day 11 (E11), E12 and E13 were analyzed.
resultsNeuronal progenitors were purified from telencephalic dissociates by a positive-selection strategy featuring surface labeling with tetanus-toxin and cholera-toxin followed by fluorescence-activated cell sorting. Microarray analyses revealed the fractions of miRNAs and mRNAs that were up-regulated or down-regulated in these neuronal progenitors at the beginning of cortical development. Nearly half of the dynamically expressed miRNAs were negatively correlated with the expression of their predicted target mRNAs.
conclusionThese data support a regulatory role for miRNAs during the transition from neuronal progenitors into the earliest differentiating cortical neurons. In addition, by supplying a robust data set in which miRNA and mRNA profiles originate from the same purified cell type, this empirical study may facilitate the development of new algorithms to integrate various "-omics" data sets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.