ArticleImmunology2009
A central role for monocytes in Toll-like receptor-mediated activation of the vasculature.
Article in Immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Extracellular DNA traps in a ctenophore demonstrate immune cell behaviors in a non-bilaterian.Nature communications · 2024Article
- Heme stimulates platelet mitochondrial oxidant production to induce targeted granule secretion.Redox biology · 2021Article
- Impact of activated monocyte and endothelial dysfunction on coagulopathy in Egyptian adult beta thalassemic patients.Hematology reports · 2020Article
- Monocytes enhance the inflammatory response to TLR2 stimulation in aortic valve interstitial cells through paracrine up-regulation of TLR2 level.International journal of biological sciences · 2020Article
- Neutrophil extracellular traps and fibrocytes in ST-segment elevation myocardial infarction.Basic research in cardiology · 2019Article
- Neutrophil elastase promotes interleukin-1β secretion from human coronary endothelium.The Journal of biological chemistry · 2015Article
- Toll-like receptor expression in the blood and brain of patients and a mouse model of Parkinson's disease.The international journal of neuropsychopharmacology · 2014Article
- Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.Journal of leukocyte biology · 2013Article
- Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice.Anesthesiology · 2012Article
- Pellino-1 selectively regulates epithelial cell responses to rhinovirus.Journal of virology · 2012Article
- Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages.Infection and immunity · 2012Article
- Role of interleukin-1 and MyD88-dependent signaling in rhinovirus infection.Journal of virology · 2011Article
- Regulation of neutrophil senescence by microRNAs.PloS one · 2011Article
- Diesel exhaust particles override natural injury-limiting pathways in the lung.American journal of physiology. Lung cellular and molecular physiology · 2010Article
- Assessing the immunopotency of Toll-like receptor agonists in an in vitro tissue-engineered immunological model.Immunology · 2010Article
- Cytokine Overproduction and Immune System Dysregulation in alloHSCT and COVID-19 Patients.Frontiers in immunologyReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
There is increasing evidence that activation of inflammatory responses in a variety of tissues is mediated co-operatively by the actions of more than one cell type. In particular, the monocyte has been implicated as a potentially important cell in the initiation of inflammatory responses to Toll-like receptor (TLR)-activating signals. To determine the potential for monocyte-regulated activation of tissue cells to underpin inflammatory responses in the vasculature, we established cocultures of primary human endothelial cells and monocytes and dissected the inflammatory responses of these systems following activation with TLR agonists. We observed that effective activation of inflammatory responses required bidirectional signalling between the monocyte and the tissue cell. Activation of cocultures was dependent on interleukin-1 (IL-1). Although monocyte-mediated IL-1beta production was crucial to the activation of cocultures, TLR specificity to these responses was also provided by the endothelial cells, which served to regulate the signalling of the monocytes. TLR4-induced IL-1beta production by monocytes was increased by TLR4-dependent endothelial activation in coculture, and was associated with increased monocyte CD14 expression. Activation of this inflammatory network also supported the potential for downstream monocyte-dependent T helper type 17 activation. These data define co-operative networks regulating inflammatory responses to TLR agonists, identify points amenable to targeting for the amelioration of vascular inflammation, and offer the potential to modify atherosclerotic plaque instability after a severe infection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.