ArticleGenes, brain, and behavior2009
Fear conditioning induces distinct patterns of gene expression in lateral amygdala.
Article in Genes, brain, and behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 59 citations in OpenAlex.
- ILF3 prion-like domain regulates gene expression and fear memory under chronic stress.iScience · 2023Article
- Cataloguing and Selection of mRNAs Localized to Dendrites in Neurons and Regulated by RNA-Binding Proteins in RNA Granules.Biomolecules · 2020Review
- Identification of Core Genes and Screening of Potential Targets in Glioblastoma Multiforme by Integrated Bioinformatic Analysis.Frontiers in oncology · 2020Article
- Mutation of the HERC 1 Ubiquitin Ligase Impairs Associative Learning in the Lateral Amygdala.Molecular neurobiology · 2018Article
- Dynamic Patterns of Threat-Associated Gene Expression in the Amygdala and Blood.Frontiers in psychiatry · 2018Article
- Brain-wide maps ofLearning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Growth hormone biases amygdala network activation after fear learning.Translational psychiatry · 2016Article
- Infralimbic EphB2 Modulates Fear Extinction in Adolescent Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Lsamp is implicated in the regulation of emotional and social behavior by use of alternative promoters in the brain.Brain structure & function · 2015Article
- Divergence of RNA localization between rat and mouse neurons reveals the potential for rapid brain evolution.BMC genomics · 2014Article
- Limbic system associated membrane protein as a potential target for neuropsychiatric disorders.Frontiers in pharmacology · 2013Article
- ABL1 in thalamus is associated with safety but not fear learning.Frontiers in systems neuroscience · 2013Article
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- IQGAP1 regulates NR2A signaling, spine density, and cognitive processes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Amygdala transcriptome and cellular mechanisms underlying stress-enhanced fear learning in a rat model of posttraumatic stress disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
The lateral nucleus of the amygdala (LA) has been implicated in the formation of long-term associative memory (LTM) of stimuli associated with danger through fear conditioning. The current study aims to detect genes that are expressed in LA following associative fear conditioning. Using oligonucleotide microarrays, we monitored gene expression in rats subjected to paired training where a tone co-terminates with a footshock, or unpaired training where the tone and footshock are presented in a non-overlapping manner. The paired protocol consistently leads to auditory fear conditioning memory formation, whereas the unpaired protocol does not. When the paired group was compared with the unpaired group 5 h after training, the expression of genes coding for the limbic system-associated membrane protein (Lsamp), kinesin heavy chain member 2 (Kif2), N-ethylmaleimide-sensitive fusion protein (NSF) and Hippocalcin-like 4 protein (Hpcal4) was higher in the paired group. These genes encode proteins that regulate neuronal axonal morphology (Lsamp, Kif2), presynaptic vesicle cycling and release (Hpcal4 and NSF), and AMPA receptor maintenance in synapses (NSF). Quantitative real-time PCR (qPCR) showed that Kif2 and Lsamp are expressed hours following fear conditioning but minutes after unpaired training. Hpcal4 is induced by paired stimulation only 5 h after the training. These results show that fear conditioning induces a unique temporal activation of molecular pathways involved in regulating synaptic transmission and axonal morphology in LA, which is different from non-associative stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.