Evidence map›Paper›PMID 19689303›Full record

ReviewCurrent molecular medicine2009

HPV as a model for the development of prophylactic and therapeutic cancer vaccines.

Raed N Samara, Samir N Khleif

Abstract readReview
In one paragraph

Review in Current molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Therapeutic vaccines for gastrointestinal cancers.Gastroenterology & hepatology · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Raed N SamaraCancer Vaccine Section, National Cancer Institute, NCI-NNMC, Bldg 10, Rm. 5101, Bethesda, MD 20889, USA.
Samir N Khleif
Graduate School USA · US

Funding

Clinical trial development in cancer vaccinesZIABC010757 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KHLEIF, SAMIR · 2009 to 2012
$1.4M
Enhancing immune response strategies:Z01BC010755 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KHLEIF, SAMIR · 2006 to 2008
$688k
Development a combined prophylactic and therapeutic cervical cancer vaccine uZ01BC010756 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KHLEIF, SAMIR · 2006 to 2008
$688k
Anti-angiogenesis targeted vaccine therapyZ01BC010752 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KHLEIF, SAMIR · 2006 to 2008
$592k
Clinical trial development in cancer vaccinesZ01BC010757 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KHLEIF, SAMIR · 2006 to 2008
$592k
Development a combined prophylactic and therapeutic cervical cancer vaccine uZIABC010756 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KHLEIF, SAMIR · 2009 to 2010
$192k
Intramural NIH HHS Z01 BC010752Intramural NIH HHS Z01 BC010755Intramural NIH HHS Z01 BC010756Intramural NIH HHS Z01 BC010757Intramural NIH HHS ZIA BC010757
6 · The paper itself

Abstract

HPV has been linked to many human malignancies and, as such, represents a major public health crisis. The understanding of HPV biology, however, has helped tremendously in developing prophylactic vaccines, which should help in decreasing mortality due to HPV infections. Understanding HPV biology has allowed researchers to use the virus as a model for the development of not only prophylactic vaccines, but also therapeutic ones. The advantages of HPV as a model stem from the limited number of proteins encoded by the HPV genome that can be targeted by vaccines, and also from the restricted expression of certain viral proteins during different stages of infection. In this review, we discuss how HPV can be used as a model for the development of both prophylactic and therapeutic vaccines.

Indexed as

Models, ImmunologicalCancer VaccinesHumansPapillomaviridaePapillomavirus InfectionsPapillomavirus VaccinesViral ProteinsCancer VaccinesPapillomavirus VaccinesViral Proteins

Identifiers

PMID19689303
PMCPMC6948838
OpenAlexW2071592067

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.