ArticleEuropean journal of immunology2009
Low cross-reactivity of T-cell responses against lipids from Mycobacterium bovis and M. avium paratuberculosis during natural infection.
Article in European journal of immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Hydrophobic Mycobacterial Antigens Elicit Polyfunctional T Cells inFrontiers in immunology · 2020Article
- The Role of Phosphatidylinositol Mannosides in the Serological Diagnosis of Mycobacterial Infections.Veterinary sciences · 2019Article
- Altered humoral immunity to mycobacterial antigens in Japanese patients affected by inflammatory demyelinating diseases of the central nervous system.Scientific reports · 2017Article
- T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Phenotypic and functional analysis of monocyte populations in cattle peripheral blood identifies a subset with high endocytic and allogeneic T-cell stimulatory capacity.Veterinary research · 2015Article
- CD1 and mycobacterial lipids activate human T cells.Immunological reviews · 2015Review
- Expression patterns of bovine CD1 in vivo and assessment of the specificities of the anti-bovine CD1 antibodies.PloS one · 2015Article
- Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- The T-Cell Response to Lipid Antigens of Mycobacterium tuberculosis.Frontiers in immunology · 2014Review
- A conserved human T cell population targets mycobacterial antigens presented by CD1b.Nature immunology · 2013Article
- A microbial glycolipid functions as a new class of target antigen for delayed-type hypersensitivity.The Journal of biological chemistry · 2011Article
- Crystal structure of bovine CD1b3 with endogenously bound ligands.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
Abstract
Although CD1 proteins are known to present mycobacterial lipid antigens to T cells, there is little understanding of the in vivo behavior of T cells restricted by CD1a, CD1b and CD1c, and the relative immunogenicity and immunodominance of individual lipids within the total array of lipids that comprise a bacterium. Because bovines express multiple CD1 proteins and are natural hosts of Mycobacterium bovis and Mycobacterium avium paratuberculosis (MAP), we used them as a new animal model of CD1 function. Here, we report the surprisingly divergent responses against lipids produced by these two pathogens during infection. Despite considerable overlap in lipid content, only three out of 69 animals cross-react with M. bovis and MAP total lipid preparations. The unidentified immunodominant compound of M. bovis is a hydrophilic compound, whereas the immunodominant lipid of MAP is presented by CD1b and was identified as glucose monomycolate (GMM). The preferential recognition of GMM antigen by MAP-infected cattle may be explained by the higher expression of GMM by MAP than by M. bovis. The bacterial species-specific nature of the CD1-restricted, adaptive T-cell response affects the approach to development of lipid based immunodiagnostic tests.
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