ReviewEuropean journal of immunology2009
Why Aire? Compensating for late bloomers.
Review in European journal of immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Twenty Years of AIRE.Frontiers in immunology · 2018Review
- Learning from a contemporary history of immunology.Immunologic research · 2017Review
- Analysis of Paris meeting redefining the "self" of the immune system.Immunologic research · 2015Article
- Serial progression of cortical and medullary thymic epithelial microenvironments.European journal of immunology · 2014Review
- Lymphopenia-induced proliferation in aire-deficient mice helps to explain their autoimmunity and differences from human patients.Frontiers in immunology · 2014Review
- Ten experiments that would make a difference in understanding immune mechanisms.Cellular and molecular life sciences : CMLS · 2012Article
- Expression of the autoimmune regulator gene and its relevance to the mechanisms of central and peripheral tolerance.Clinical & developmental immunology · 2012Review
- The evolutionary context for a self-nonself discrimination.Cellular and molecular life sciences : CMLS · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The question under analysis in this commentary is, what was the evolutionary selection pressure that necessitated the ectopic expression of a subset of peripheral self-antigens in the thymus and by peripheral APC? The suggestion is that antigen expression is delayed until after the immune system is responsive.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.