ArticlePflugers Archiv : European journal of physiology2009
Erg K+ currents modulate excitability in mouse mitral/tufted neurons.
Article in Pflugers Archiv : European journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- The Role of Loss-of-Function KCNH2 Variants in Cardiac Arrhythmias, Seizures and the Risk of Sudden Unexpected Death in Epilepsy.Journal of neurochemistry · 2026Review
- Knock-in Kcnh2 rabbit model of long QT syndrome type-2, epilepsy, and sudden death.Journal of translational medicine · 2025Article
- Purkinje cell hyperexcitability and depressive-like behavior in mice lacking erg3 (ether-à-go-go-related gene) KScience advances · 2024Article
- Review
- The Effectiveness of Isoplumbagin and Plumbagin in Regulating Amplitude, Gating Kinetics, and Voltage-Dependent Hysteresis ofBiomedicines · 2022Article
- The ERG1 KFrontiers in molecular neuroscience · 2022Review
- ERG3 potassium channel-mediated suppression of neuronal intrinsic excitability and prevention of seizure generation in mice.The Journal of physiology · 2018Article
- Ether-à-go-go KThe Journal of physiology · 2018Review
- Adenosine AThe Journal of physiology · 2018Article
- Inverse Modulation of Neuronal KFrontiers in molecular neuroscience · 2018Article
- hERG1 potassium channel in cancer cells: a tool to reprogram immortality.European biophysics journal : EBJ · 2016Review
- Ginsenoside Rg3, a Gating Modifier of EAG Family K+ Channels.Molecular pharmacology · 2016Article
- Effects of Temperature on Heteromeric Kv11.1a/1b and Kv11.3 Channels.Biophysical journal · 2016Article
- Ether-à-go-go family voltage-gated K+ channels evolved in an ancestral metazoan and functionally diversified in a cnidarian-bilaterian ancestor.The Journal of experimental biology · 2015Article
- Erg potassium currents of neonatal mouse Purkinje cells exhibit fast gating kinetics and are inhibited by mGluR1 activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- hERG channel function: beyond long QT.Acta pharmacologica Sinica · 2013Review
- Inhibition of HERG1 K+ channel protein expression decreases cell proliferation of human small cell lung cancer cells.Pflugers Archiv : European journal of physiology · 2012Article
- Article
- Expression pattern of Kv11 (Ether à-go-go-related gene; erg) K+ channels in the mouse retina.PloS one · 2011Article
- New Trends in Cancer Therapy: Targeting Ion Channels and Transporters.Pharmaceuticals (Basel, Switzerland) · 2010Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Different erg (ether-à-go-go-related gene; Kv11) K+ channel subunits are expressed throughout the brain. Especially mitral cells of the olfactory bulb are stained intensely by erg1a, erg1b, erg2, and erg3 antibodies. This led us to study the erg current in mitral/tufted (M/T) neurons from mouse olfactory bulb in primary culture. M/T neurons were identified by their morphology and presence of mGluR1 receptors, and RT-PCR demonstrated the expression of all erg subunits in cultured M/T neurons. Using an elevated external K+ concentration, a relatively uniform erg current was recorded in the majority of M/T cells and isolated with the erg channel blocker E-4031. With 4-s depolarizations, the erg current started to activate at -65 mV and exhibited half maximal activation at -51 mV. An increase in the external K+ concentration resulted in an increase in erg whole-cell conductance. The specific group 1 mGluR agonist, DHPG, which depolarizes mitral cells, reduced erg channel availability. DHPG accelerated erg current deactivation, reduced the maximum current amplitude, and shifted availability and activation curves to more depolarized potentials. A pharmacological block of erg channels depolarized the resting potential of M/T cells and clearly demonstrated the involvement of erg channels in the control of mitral cell excitability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.