ArticleMolecular biology reports2010
Analysis on cDNA sequence, mRNA expression and imprinting status of Dlk1 gene in goats.
Article in Molecular biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 5 citations in OpenAlex.
- Polar Overdominance Inheritance ofInternational journal of molecular sciences · 2026Article
- Delta-like 1 homolog in Capra hircus: molecular characteristics, expression pattern and phylogeny.Molecular biology reports · 2016Article
- Molecular cloning, sequence identification and tissue expression profile of three novel genes Sfxn1, Snai2 and Cno from Black-boned sheep (Ovis aries).Molecular biology reports · 2011Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dlk1 (Delta-like homolog 1) is a cell surface transmembrane glycoprotein belonging to the epidermal growth factor like family of homeotic proteins and plays an important role in regulating fetal and postnatal development. Increased expression of Dlk1 is the primary cause of muscle hypertrophy in the callipyge sheep exhibiting overgrowth of fast-twitch muscles and reduced adiposity. However, the function of Dlk1 in goats remains unknown. In this study, a fragment of 864 bp of goat Dlk1 cDNA, encoding 287 amino acids, was amplified, which has a high homology both in nucleotide sequence and amino acid sequence with the corresponding region of pig, cattle and sheep Dlk1. The Dlk1 was found to be expressed in most tissues of goat fetuses, and in the adrenal gland, pancreas and thymus of adult goats. Two alternative transcripts of Dlk1-C and Dlk1-C2 were expressed in both fetuses and adult goats. One C/T transition in the coding region of goat Dlk1 was identified and by genotyping one segregating goat family and the expressed allele in the tissues of the offspring, Dlk1 was found to be paternally expressed.
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