ReviewSleep & breathing = Schlaf & Atmung2010
Effects of interval hypoxia on exercise tolerance: special focus on patients with CAD or COPD.
Review in Sleep & breathing = Schlaf & Atmung, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06451601 (The Metabolic and Respiratory Effects of Intermittent Hypoxia-hyperoxia Therapy in Obese Patients Within the Complex Management of Medical Rehabilitation), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Metabolic and Respiratory Effects of Intermittent Hypoxia-hyperoxia Therapy in Obese Patients Within the Complex Management of Medical Rehabilitation
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Safety and Efficacy of Intermittent Hypoxia Conditioning as a New Rehabilitation/ Secondary Prevention Strategy for Patients with Cardiovascular Diseases: A Systematic Review and Meta-analysis.Current cardiology reviews · 2021Pooled it
- Exploring Hypoxia-Induced Neuroprotection Mechanisms in Post-Stroke Recovery.Translational stroke research · 2025Review
- Physiological and molecular mechanisms of tolerance to hypoxia and oxygen deficiency resistance markers.Frontiers in molecular biosciences · 2025Review
- Article
- Effects of Hypoxia on Cerebral Microvascular Angiogenesis: Benefits or Damages?Aging and disease · 2023Review
- Effectiveness of Intermittent Hypoxia-Hyperoxia Therapy in Different Pathologies with Possible Metabolic Implications.Metabolites · 2023Review
- A mito-centric view on muscle aging and function.Frontiers in public health · 2023Article
- Intermittent Hypoxia Conditioning: A Potential Multi-Organ Protective Therapeutic Strategy.International journal of medical sciences · 2023Review
- Editorial: Hypoxia in cardiovascular disease.Frontiers in cardiovascular medicine · 2022Article
- Intermittent Hypoxic Training as an Effective Tool for Increasing the Adaptive Potential, Endurance and Working Capacity of the Brain.Frontiers in neuroscience · 2022Review
- Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain.Alzheimer's research & therapy · 2021Article
- Intermittent Hypoxic Preconditioning: A Potential New Powerful Strategy for COVID-19 Rehabilitation.Frontiers in pharmacology · 2021Review
- Altitude and COVID-19: Friend or foe? A narrative review.Physiological reports · 2021Review
- Lipolysis by downregulating miR-92a activates the Wnt/β-catenin signaling pathway in hypoxic rats.Biomedical reports · 2020Article
- Comparison of the Effectiveness of High-Intensity Interval Training in Hypoxia and Normoxia in Healthy Male Volunteers: A Pilot Study.BioMed research international · 2019Article
- Overlap syndrome of COPD and OSA in Koreans.Medicine · 2017Article
- Adaptations following an intermittent hypoxia-hyperoxia training in coronary artery disease patients: a controlled study.Clinical cardiology · 2017Article
- Pre-endurance training prevents acute alcoholic liver injury in rats through the regulation of damaged mitochondria accumulation and mitophagy balance.Hepatology international · 2014Article
- Article
- The roles of exercise tolerance and resilience in the effect of physical activity on emotional states among college students.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRepeated short-term hypoxia (interval hypoxia) has been suggested to increase exercise tolerance by enhancing stress resistance and/or improving oxygen delivery. As low exercise tolerance contributes to mortality in patients with coronary artery disease (CAD) and chronic obstructive pulmonary disease (COPD), interval hypoxia might be a valuable preventive and therapeutic tool for these patients. Yet, mechanisms responsible for the improvement of exercise tolerance are still largely unknown. Therefore, this review intends to present an overview for better understanding of such mechanisms and to stimulate further research work on this important topic. DATA SOURCE: Articles were selected from a search of the PubMed database up to 2009 using the search terms hypoxia, intermittent, interval in various combinations with exercise, capacity, tolerance, CAD, COPD, and various haematological and cardio-respiratory parameters.
resultsGenerally, the effects of 2-4 weeks of interval hypoxia on exercise tolerance are contrasting. Whereas aerobic exercise performance improved or remained unchanged, anaerobic performance tended even to worsen. Benefits on exercise tolerance seem to be greater in patients with CAD or COPD when compared to healthy subjects. DISCUSSION: The mechanisms responsible for these benefits are the increases in total haemoglobin mass, lung diffusion capacity, more efficient ventilation, and a decrease in the responsiveness of the adrenergic system to stimulation and/or an increase in parasympathetic activity. If confirmed in further studies, interval hypoxia might become an attractive strategy to complement the known beneficial effects of exercise training, especially in patients with CAD or COPD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.