Evidence map›Paper›PMID 19687790›Full record

SynthesisNature reviews. Cardiology2009

Vitamin D status and arterial hypertension: a systematic review.

Stefan Pilz, Andreas Tomaschitz, Eberhard Ritz, Thomas R Pieber

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Nature reviews. Cardiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 9 pooled it
25.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 9 syntheses or guidelines pooled it, 403 citations in OpenAlex.

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  17. Therapeutic implications of vitamin D and calcium in overweight women with polycystic ovary syndrome.Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2012
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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Stefan PilzDepartment of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Medical University of Graz, Austria. stefan.pilz@chello.at
Andreas Tomaschitz
Eberhard Ritz
Thomas R Pieber
Medical University of Graz · ATHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D deficiency is common and is primarily caused by a lack of ultraviolet-B (UVB) radiation from reduced sun exposure, and the consequent limiting of vitamin D production in the skin. The vitamin D endocrine system regulates about 3% of the human genome. Observational data support the concept that vitamin D is involved in the pathogenesis of cardiovascular diseases and arterial hypertension. The antihypertensive properties of vitamin D include renoprotective effects, suppression of the renin-angiotensin-aldosterone system, direct effects on vascular cells, and effects on calcium metabolism, including prevention of secondary hyperparathyroidism. The results of clinical studies largely, but not consistently, favor the hypothesis that vitamin D sufficiency promotes lowering of arterial blood pressure. Randomized, placebo-controlled trials are greatly needed to clarify and definitively prove the effect of vitamin D on blood pressure. In general, the antihypertensive effects of vitamin D seem to be particularly prominent in vitamin-D-deficient patients with elevated blood pressure. Thus, in view of the relatively safe and inexpensive way in which vitamin D can be supplemented, we believe that vitamin D supplementation should be prescribed to patients with hypertension and 25-hydroxyvitamin D levels below target values.

Indexed as

Dietary SupplementsAnimalsAntihypertensive AgentsBlood PressureCalciumEvidence-Based MedicineHumansHypertensionRenin-Angiotensin SystemTreatment OutcomeVitamin DVitamin D DeficiencyAntihypertensive AgentsCalciumVitamin D

Identifiers

PMID19687790
OpenAlexW2018943212

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.