ArticleMolecular and cellular biology2009
FoxA1 binding directs chromatin structure and the functional response of a glucocorticoid receptor-regulated promoter.
Article in Molecular and cellular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- The urothelial gene regulatory network: understanding biology to improve bladder cancer management.Oncogene · 2024Review
- Identifying chromatin features that regulate gene expression distribution.Scientific reports · 2020Article
- Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci.Cell reports · 2017Article
- Glucocorticoid Receptor:MegaTrans Switching Mediates the Repression of an ERα-Regulated Transcriptional Program.Molecular cell · 2017Article
- Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.American journal of human genetics · 2016Article
- Article
- Quantification of transcription factor-DNA binding affinity in a living cell.Nucleic acids research · 2016Article
- Heregulin Co-opts PR Transcriptional Action Via Stat3 Role As a Coregulator to Drive Cancer Growth.Molecular endocrinology (Baltimore, Md.) · 2015Article
- ChIP-exo signal associated with DNA-binding motifs provides insight into the genomic binding of the glucocorticoid receptor and cooperating transcription factors.Genome research · 2015Article
- FOXA1 positively regulates gene expression by changing gene methylation status in human breast cancer MCF-7 cells.International journal of clinical and experimental pathology · 2015Article
- Remodeling of retrotransposon elements during epigenetic induction of adult visual cortical plasticity by HDAC inhibitors.Epigenetics & chromatin · 2015Article
- Minireview: pioneer transcription factors in cell fate specification.Molecular endocrinology (Baltimore, Md.) · 2014Review
- NFI transcription factors interact with FOXA1 to regulate prostate-specific gene expression.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Modulation of androgen receptor by FOXA1 and FOXO1 factors in prostate cancer.International journal of biological sciences · 2014Review
- Chromatin architecture defines the glucocorticoid response.Molecular and cellular endocrinology · 2013Review
- High-throughput RNA FISH analysis by imaging flow cytometry reveals that pioneer factor Foxa1 reduces transcriptional stochasticity.PloS one · 2013Article
- Estradiol antagonism of glucocorticoid-induced GILZ expression in human uterine epithelial cells and murine uterus.Endocrinology · 2013Article
- The hypersensitive glucocorticoid response specifically regulates period 1 and expression of circadian genes.Molecular and cellular biology · 2012Article
- Impact of chromatin structure on PR signaling: transition from local to global analysis.Molecular and cellular endocrinology · 2012Review
- Analysis of chromatin dynamics during glucocorticoid receptor activation.Molecular and cellular biology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reconstitution of the glucocorticoid receptor (GR)-regulated mouse mammary tumor virus (MMTV) promoter in Xenopus oocytes was used to monitor the effects of different transcription factor contexts. Three constitutively binding factors, nuclear factor 1 (NF1), octamer transcription factor 1 (Oct1), and the Forkhead box A1 (FoxA1), were shown to act in concert, to direct the chromatin structure, and to enhance the GR response. FoxA1 has a dominant effect in the absence of hormone and induces a cluster of DNase I-hypersensitive sites in the segment comprising bp -400 to +25. This FoxA1-mediated chromatin remodeling does not induce MMTV transcription, as opposed to that of the GR. However, the robust FoxA1-dependent chromatin opening has the following drastic functional consequences on the hormone regulation: (i) GR-DNA binding is facilitated, as revealed by dimethyl sulfate in vivo footprinting, leading to increased hormone-induced transcription, and (ii) the GR antagonist RU486 is converted into a partial agonist in the presence of FoxA1 via ligand-independent GR activation. We conclude that FoxA1 mediates a preset chromatin structure and directs a context-specific response of a nuclear receptor. Furthermore, the alternative nucleosome arrangement induced by GR and FoxA1 implies this to be determined by constitutive binding of transcription factors rather than by the DNA sequence itself.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.