ArticleMolecular and cellular biology2009
Chromatin architecture and transcription factor binding regulate expression of erythrocyte membrane protein genes.
Article in Molecular and cellular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Erythropoiesis: insights from a genomic perspective.Experimental & molecular medicine · 2024Review
- Association of metallothionein 2A rs10636 with low mean corpuscular volume (MCV), low mean corpuscular haemoglobin (MCH) in healthy Taiwanese.Scientific reports · 2023Article
- A Unique Epigenomic Landscape Defines Human Erythropoiesis.Cell reports · 2019Article
- Erythropoietin Signaling Regulates Key Epigenetic and Transcription Networks in Fetal Neural Progenitor Cells.Scientific reports · 2017Article
- GATA1 Activity Governed by Configurations ofFrontiers in oncology · 2016Review
- CTCF and CohesinSA-1 Mark Active Promoters and Boundaries of Repressive Chromatin Domains in Primary Human Erythroid Cells.PloS one · 2016Article
- The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1β and NF-κB signaling.Journal of cell science · 2015Article
- Histone methyltransferase Setd8 represses Gata2 expression and regulates erythroid maturation.Molecular and cellular biology · 2015Article
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- Physiological functions of MTA family of proteins.Cancer metastasis reviews · 2014Review
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- Identification of biologically relevant enhancers in human erythroid cells.The Journal of biological chemistry · 2013Article
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- Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis.Blood · 2012Article
- Tropomodulins: pointed-end capping proteins that regulate actin filament architecture in diverse cell types.Cytoskeleton (Hoboken, N.J.) · 2012Review
- Review
- A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.The Journal of experimental medicine · 2012Article
- Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.PloS one · 2012Article
- Patterns of histone H3 lysine 27 monomethylation and erythroid cell type-specific gene expression.The Journal of biological chemistry · 2011Article
- Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Erythrocyte membrane protein genes serve as excellent models of complex gene locus structure and function, but their study has been complicated by both their large size and their complexity. To begin to understand the intricate interplay of transcription, dynamic chromatin architecture, transcription factor binding, and genomic organization in regulation of erythrocyte membrane protein genes, we performed chromatin immunoprecipitation (ChIP) coupled with microarray analysis and ChIP coupled with massively parallel DNA sequencing in both erythroid and nonerythroid cells. Unexpectedly, most regions of GATA-1 and NF-E2 binding were remote from gene promoters and transcriptional start sites, located primarily in introns. Cooccupancy with FOG-1, SCL, and MTA-2 was found at all regions of GATA-1 binding, with cooccupancy of SCL and MTA-2 also found at regions of NF-E2 binding. Cooccupancy of GATA-1 and NF-E2 was found frequently. A common signature of histone H3 trimethylation at lysine 4, GATA-1, NF-E2, FOG-1, SCL, and MTA-2 binding and consensus GATA-1-E-box binding motifs located 34 to 90 bp away from NF-E2 binding motifs was found frequently in erythroid cell-expressed genes. These results provide insights into our understanding of membrane protein gene regulation in erythropoiesis and the regulation of complex genetic loci in erythroid and nonerythroid cells and identify numerous candidate regions for mutations associated with membrane-linked hemolytic anemia.
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