ArticleInfection and immunity2009
Identification of a modular pathogenicity island that is widespread among urease-producing uropathogens and shares features with a diverse group of mobile elements.
Article in Infection and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
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- Microbial communities, antibiotic resistance genes, and virulence factors in urinary infectious stone-associated urinary tract infections.Urolithiasis · 2024Article
- Genomic analysis reveals the role of integrative and conjugative elements in plant pathogenic bacteria.Mobile DNA · 2022Article
- A Genomic and Bioinformatics View of the Classification and Evolution ofMicrobiology spectrum · 2022Article
- Genetic Characterization of Four Groups of Chromosome-Borne Accessory Genetic Elements Carrying Drug Resistance Genes inInfection and drug resistance · 2022Article
- Clinical Molecular and Genomic Epidemiology ofFrontiers in microbiology · 2021Article
- Pathogenesis ofEcoSal Plus · 2018Review
- Comparative Genomic Analysis of a Clinical Isolate ofFrontiers in microbiology · 2018Article
- Characterization and genomic analyses of two newly isolated Morganella phages define distant members among Tevenvirinae and Autographivirinae subfamilies.Scientific reports · 2017Article
- Proteus mirabilis and Urinary Tract Infections.Microbiology spectrum · 2015Review
- A Transmissible Plasmid-Borne Pathogenicity Island Confers Piscibactin Biosynthesis in the Fish Pathogen Photobacterium damselae subsp. piscicida.Applied and environmental microbiology · 2015Article
- Merging mythology and morphology: the multifaceted lifestyle of Proteus mirabilis.Nature reviews. Microbiology · 2012Review
- Iron acquisition in the marine actinomycete genus Salinispora is controlled by the desferrioxamine family of siderophores.FEMS microbiology letters · 2012Article
- Whole-genome sequencing and identification of Morganella morganii KT pathogenicity-related genes.BMC genomics · 2012Article
- Self-transmissibility of the integrative and conjugative element ICEPm1 between clinical isolates requires a functional integrase, relaxase, and type IV secretion system.Journal of bacteriology · 2011Article
- Transcriptome of Proteus mirabilis in the murine urinary tract: virulence and nitrogen assimilation gene expression.Infection and immunity · 2011Article
- Proteobactin and a yersiniabactin-related siderophore mediate iron acquisition in Proteus mirabilis.Molecular microbiology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Pathogenicity islands (PAIs) are a specific group of genomic islands that contribute to genomic variability and virulence of bacterial pathogens. Using a strain-specific comparative genomic hybridization array, we report the identification of a 94-kb PAI, designated ICEPm1, that is common to Proteus mirabilis, Providencia stuartii, and Morganella morganii. These organisms are highly prevalent etiologic agents of catheter-associated urinary tract infections (caUTI), the most common hospital acquired infection. ICEPm1 carries virulence factors that are important for colonization of the urinary tract, including a known toxin (Proteus toxic agglutinin) and the high pathogenicity island of Yersinia spp. In addition, this PAI shares homology and gene organization similar to the PAIs of other bacterial pathogens, several of which have been classified as mobile integrative and conjugative elements (ICEs). Isolates from this study were cultured from patients with caUTI and show identical sequence similarity at three loci within ICEPm1, suggesting its transfer between bacterial genera. Screening for the presence of ICEPm1 among P. mirabilis colonizing isolates showed that ICEPm1 is more prevalent in urine isolates compared to P. mirabilis strains isolated from other body sites (P<0.0001), further suggesting that it contributes to niche specificity and is positively selected for in the urinary tract.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.