ArticleJournal of immunology (Baltimore, Md. : 1950)2009
Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
79 citing papers in PubMed, 189 citations in OpenAlex.
- MOG antibody-associated optic neuritis.Eye (London, England) · 2024Review
- Evolution in anti-myelin oligodendrocyte glycoprotein antibody detection and its clinical significance: a narrative review.Annals of translational medicine · 2023Review
- Experimental laboratory biomarkers in multiple sclerosis.Wiener medizinische Wochenschrift (1946) · 2022Review
- Clinical and neuroimaging findings in MOGAD-MRI and OCT.Clinical and experimental immunology · 2021Review
- gAChR antibodies in children and adolescents with acquired autoimmune dysautonomia in Japan.Annals of clinical and translational neurology · 2021Article
- Single-cell approaches to investigate B cells and antibodies in autoimmune neurological disorders.Cellular & molecular immunology · 2021Review
- Clinical and transcriptional recovery profiles in pediatric and adult multiple sclerosis patients.Annals of clinical and translational neurology · 2021Article
- Pathogenesis of autoimmune demyelination: from multiple sclerosis to neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody-associated disease.Clinical & translational immunology · 2021Review
- Oligodendrocyte myelin glycoprotein as a novel target for pathogenic autoimmunity in the CNS.Acta neuropathologica communications · 2020Article
- Acute Disseminated Encephalomyelitis: Current Perspectives.Children (Basel, Switzerland) · 2020Review
- Identification of TNFAIP3 as relapse biomarker and potential therapeutic target for MOG antibody associated diseases.Scientific reports · 2020Article
- International multicenter examination of MOG antibody assays.Neurology(R) neuroimmunology & neuroinflammation · 2020Article
- Delayed-Release Dimethyl Fumarate Safety and Efficacy in Pediatric Patients With Relapsing-Remitting Multiple Sclerosis.Frontiers in neurology · 2020Article
- Recent developments in MOG-IgG associated neurological disorders.Therapeutic advances in neurological disorders · 2020Review
- Effects of the Positive Threshold and Data Analysis on Human MOG Antibody Detection by Live Flow Cytometry.Frontiers in immunology · 2020Article
- Molecular biomarkers in multiple sclerosis.Journal of neuroinflammation · 2019Review
- Diagnostic Considerations in Acute Disseminated Encephalomyelitis and the Interface with MOG Antibody.Neuropediatrics · 2019Review
- Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination.Acta neuropathologica communications · 2019Article
- Impact of B cells to the pathophysiology of multiple sclerosis.Journal of neuroinflammation · 2019Review
- The Multiple Roles of B Cells in Multiple Sclerosis and Their Implications in Multiple Sclerosis Therapies.Cold Spring Harbor perspectives in medicine · 2019Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
24 authors at 14 institutions in 10 countries.
Funding
Abstract
Multiple sclerosis (MS) typically manifests in early to mid adulthood, but there is increasing recognition of pediatric-onset MS, aided by improvements in imaging techniques. The immunological mechanisms of disease are largely unexplored in pediatric-onset MS, in part because studies have historically focused on adult-onset disease. We investigated autoantibodies to myelin surface Ags in a large cohort of pediatric MS cases by flow cytometric labeling of transfectants that expressed different myelin proteins. Although Abs to native myelin oligodendrocyte glycoprotein (MOG) were uncommon among adult-onset patients, a subset of pediatric patients had serum Abs that brightly labeled the MOG transfectant. Abs to two other myelin surface Ags were largely absent. Affinity purification of MOG Abs as well as competition of binding with soluble MOG documented their binding specificity. Such affinity purified Abs labeled myelin and glial cells in human CNS white matter as well as myelinated axons in gray matter. The prevalence of such autoantibodies was highest among patients with a very early onset of MS: 38.7% of patients less than 10 years of age at disease onset had MOG Abs, compared with 14.7% of patients in the 10- to 18-year age group. B cell autoimmunity to this myelin surface Ag is therefore most common in patients with a very early onset of MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.