ArticleJournal of neurology, neurosurgery, and psychiatry2010
Cardiac neurotransmission imaging with 123I-meta-iodobenzylguanidine in postural tachycardia syndrome.
Article in Journal of neurology, neurosurgery, and psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Hyperadrenergic and neuropathic features based on clinical autonomic testing in individuals with POTS: an observational cross-sectional study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Illuminating the Hidden: Standardizing Cardiac MIBG Imaging for Sympathetic Dysfunction.Journal of nuclear medicine technology · 2025Review
- Postural tachycardia syndrome: current perspectives.Vascular health and risk management · 2018Review
- Sleep disturbances and autonomic dysfunction in patients with postural orthostatic tachycardia syndrome.Frontiers in neurology · 2014Article
- Sympathetic dysfunction in vasovagal syncope and the postural orthostatic tachycardia syndrome.Frontiers in physiology · 2014Review
- Gastric emptying in postural tachycardia syndrome: a preliminary report.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2013Article
- Postural tachycardia syndrome: a heterogeneous and multifactorial disorder.Mayo Clinic proceedings · 2012Review
- Postural tachycardia syndrome--current experience and concepts.Nature reviews. Neurology · 2011Review
- New onset postural orthostatic tachycardia syndrome following ablation of AV node reentrant tachycardia.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2010Article
- Beyond postural tachycardia syndrome.Journal of neurology, neurosurgery, and psychiatry · 2010Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostural orthostatic tachycardia syndrome (POTS) is a disorder of orthostatic intolerance characterised by excessive tachycardia of unknown aetiology. Whether this condition involves abnormal cardiac sympathetic innervation or function remains elusive. Meta-iodobenzylguanidine (MIBG) resembles guanethidine and is a pharmacologically inactive analogue of norepinephrine, which is similarly metabolised in noradrenergic neurons. MIBG myocardial scintigraphy is used clinically to estimate local myocardial sympathetic nerve damage in some forms of heart disease and autonomic neuropathy. The objective of this study was to evaluate cardiac sympathetic innervation in patients with POTS.
methods20 patients with POTS were studied using (123)I-MIBG-single photon emission computed tomography, standardised autonomic testing, assessment of catecholamine plasma levels and sympathetic skin response.
resultsIn four POTS patients (20.0%), myocardial MIBG uptake was markedly decreased. The mean heart to mediastinum ratio was reduced to 1.22+/-0.08 compared with the normal range of >1.7. No correlation was found between myocardial MIBG uptake and degree of postural tachycardia, baroreflex sensitivity, catecholamine plasma levels or other autonomic parameters. Sympathetic skin responses were normal in all patients.
conclusionsThese findings suggest that POTS may be, in part, a manifestation of autonomic cardiac neuropathy. MIBG myocardial scintigraphy may be helpful to distinguish patients with neuropathic POTS from patients with orthostatic intolerance of other origin.
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