ArticleExperimental cell research2010
Experimental control of excitable embryonic tissues: three stimuli induce rapid epithelial contraction.
Article in Experimental cell research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 40 citations in OpenAlex.
- Zyxin and LPP differ in their sensing of strained actin filaments at tricellular junctions.bioRxiv : the preprint server for biology · 2026Article
- Supracellular contractility in Xenopus embryo epithelia regulated by extracellular ATP and the purinergic receptor P2Y2.Journal of cell science · 2025Article
- Mechanosensitive recruitment of Vinculin maintains junction integrity and barrier function at epithelial tricellular junctions.Current biology : CB · 2024Article
- Embryos assist morphogenesis of others through calcium and ATP signaling mechanisms in collective teratogen resistance.Nature communications · 2024Article
- Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells.Developmental cell · 2021Article
- Anillin regulates epithelial cell mechanics by structuring the medial-apical actomyosin network.eLife · 2019Article
- Strain-triggered mechanical feedback in self-organizing optic-cup morphogenesis.Science advances · 2018Article
- Article
- Endogenous Bioelectric Signaling Networks: Exploiting Voltage Gradients for Control of Growth and Form.Annual review of biomedical engineering · 2017Review
- Maintenance of the Epithelial Barrier and Remodeling of Cell-Cell Junctions during Cytokinesis.Current biology : CB · 2016Article
- Calcium-dependent neuroepithelial contractions expel damaged cells from the developing brain.Developmental cell · 2014Article
- Mechanochemical actuators of embryonic epithelial contractility.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Biomechanics and the thermotolerance of development.PloS one · 2014Article
- The interplay between cell signalling and mechanics in developmental processes.Nature reviews. Genetics · 2013Review
- The role of transcription-independent damage signals in the initiation of epithelial wound healing.Nature reviews. Molecular cell biology · 2013Review
- Epithelial machines of morphogenesis and their potential application in organ assembly and tissue engineering.Biomechanics and modeling in mechanobiology · 2012Review
- Local small airway epithelial injury induces global smooth muscle contraction and airway constriction.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Microscopy tools for quantifying developmental dynamics in Xenopus embryos.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Quantitative microscopy and imaging tools for the mechanical analysis of morphogenesis.Current opinion in genetics & development · 2011Review
- Mechanosensitive shivering of model tissues under controlled aspiration.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cell generated contractility is a major driver of morphogenesis during processes such as epithelial bending and epithelial-to-mesenchymal transitions. Previous studies of contraction in embryos have relied on developmentally programmed cell shape changes such as those that accompany ventral furrow formation in Drosophila, bottle cell formation in Xenopus, ingression in amniote embryos, and neurulation in vertebrate embryos. We have identified three methods to reproducibly and acutely induce contraction in embryonic epithelial sheets: laser activation, electrical stimulation, and nano-perfusion with chemicals released by wounding. Contractions induced by all three methods occur over a similar time-scale (1 to 2 min) and lead to reorganization of the F-actin cytoskeleton. By combining induced contractions with micro-aspiration we can simultaneously measure the stiffness of the tissue and the force and work done by contractions. Laser activation allows real-time visualization of F-actin remodeling during contraction. Perfusion with cell lysate suggests that these three stimuli activate physiologically relevant pathways that maintain epithelial tension or trigger epithelial morphogenesis. Our methods provide the means to control and study cellular contractility and will allow dissection of molecular mechanisms and biomechanics of cellular contractility.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.