ArticleDevelopmental cell2009
PAR-1 phosphorylates Mind bomb to promote vertebrate neurogenesis.
Article in Developmental cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 67 citations in OpenAlex.
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- Pinhead signaling regulates mesoderm heterogeneity via the FGF receptor-dependent pathway.Development (Cambridge, England) · 2020Article
- Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.Scientific reports · 2019Article
- Isolation of nanobodies against Xenopus embryonic antigens using immune and non-immune phage display libraries.PloS one · 2019Article
- Par3 interacts with Prickle3 to generate apical PCP complexes in the vertebrate neural plate.eLife · 2018Article
- The Ajuba family protein Wtip regulates actomyosin contractility during vertebrate neural tube closure.Journal of cell science · 2018Article
- Mib1 prevents Notch Cis-inhibition to defer differentiation and preserve neuroepithelial integrity during neural delamination.PLoS biology · 2018Article
- EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity.Nature cell biology · 2017Article
- Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2.eLife · 2017Article
- Article
- Active zone proteins are transported via distinct mechanisms regulated by Par-1 kinase.PLoS genetics · 2017Article
- Partitioning-Defective 1a/b Depletion Impairs Glomerular and Proximal Tubule Development.Journal of the American Society of Nephrology : JASN · 2016Article
- Satellite Cells in Muscular Dystrophy - Lost in Polarity.Trends in molecular medicine · 2016Review
- Prickle3 synergizes with Wtip to regulate basal body organization and cilia growth.Scientific reports · 2016Article
- The Notch ligand E3 ligase, Mind Bomb1, regulates glutamate receptor localization in Drosophila.Molecular and cellular neurosciences · 2016Article
- The involvement of PCP proteins in radial cell intercalations during Xenopus embryonic development.Developmental biology · 2015Article
- Planar polarization of Vangl2 in the vertebrate neural plate is controlled by Wnt and Myosin II signaling.Biology open · 2015Article
- Vangl2 cooperates with Rab11 and Myosin V to regulate apical constriction during vertebrate gastrulation.Development (Cambridge, England) · 2015Article
- Association of new deletion/duplication region at chromosome 1p21 with intellectual disability, severe speech deficit and autism spectrum disorder-like behavior: an all-in approach to solving theTranslational neuroscience · 2015Review
- Getting to know your neighbor: cell polarization in early embryos.The Journal of cell biology · 2014Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Generation of neurons in the vertebrate central nervous system requires a complex transcriptional regulatory network and signaling processes in polarized neuroepithelial progenitor cells. Here we demonstrate that neurogenesis in the Xenopus neural plate in vivo and mammalian neural progenitors in vitro involves intrinsic antagonistic activities of the polarity proteins PAR-1 and aPKC. Furthermore, we show that Mind bomb (Mib), a ubiquitin ligase that promotes Notch ligand trafficking and activity, is a crucial molecular substrate for PAR-1. The phosphorylation of Mib by PAR-1 results in Mib degradation, repression of Notch signaling, and stimulation of neuronal differentiation. These observations suggest a conserved mechanism for neuronal fate determination that might operate during asymmetric divisions of polarized neural progenitor cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.