Evidence map›Paper›PMID 19686673›Full record

ArticleDevelopmental cell2009

Notch signaling: linking delta endocytosis and cell polarity.

Michael P Krahn, Andreas Wodarz

Abstract readComment
PubMed Publisher
In one paragraph

Article in Developmental cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. PeerJ · 2018
    Article
  2. Article
  3. Article
  4. DeltaA mRNA and protein distribution in the zebrafish nervous system.Developmental dynamics : an official publication of the American Association of Anatomists · 2009
    Article
  5. Initial neurogenesis in Drosophila.Wiley interdisciplinary reviews. Developmental biology
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Michael P KrahnAbteilung Stammzellbiologie, DFG Research Center for Molecular Physiology of the Brain, Georg-August-Universität Göttingen, Justus-von-Liebig-Weg 11, Göttingen 37077, Germany.
Andreas Wodarz

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activation of Notch by its transmembrane ligand Delta requires the E3 ubiquitin ligases Neuralized or Mind bomb and endocytosis of the ubiquitinated ligand. In this issue of Developmental Cell, Ossipova et al. show that the polarity regulator PAR-1 phosphorylates Mind bomb, leading to the degradation of Mind bomb and to changes in cell fate due to loss of Notch signaling.

Indexed as

Cell PolarityAnimalsDrosophila ProteinsEndocytosisGlycogen Synthase Kinase 3Intracellular Signaling Peptides and ProteinsIsoenzymesMembrane ProteinsProtein Kinase CProtein Serine-Threonine KinasesReceptors, NotchSignal TransductionUbiquitin-Protein Ligasesdelta proteinDrosophila ProteinsGlycogen Synthase Kinase 3Intracellular Signaling Peptides and ProteinsIsoenzymesMembrane ProteinsMib1 protein, DrosophilaPar-1 protein, DrosophilaProtein Kinase CProtein Serine-Threonine KinasesReceptors, NotchUbiquitin-Protein Ligases

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.