ArticleBiophysical journal2009
Twirling motion of actin filaments in gliding assays with nonprocessive Myosin motors.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Membrane-bound myosin IC drives the chiral rotation of the gliding actin filament around its longitudinal axis.Scientific reports · 2023Article
- CYK-1/Formin activation in cortical RhoA signaling centers promotes organismal left-right symmetry breaking.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Mechanical stress induces a scalable switch in cortical flow polarization during cytokinesis.Journal of cell science · 2019Article
- Working stroke of the kinesin-14, ncd, comprises two substeps of different direction.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Force Generation by Membrane-Associated Myosin-I.Scientific reports · 2016Article
- Myosin S2 origins track evolution of strong binding on actin by azimuthal rolling of motor domain.Biophysical journal · 2015Article
- Ensemble velocity of non-processive molecular motors with multiple chemical states.Interface focus · 2014Article
- Active chiral fluids.The European physical journal. E, Soft matter · 2012Article
- Quasiperiodic distribution of rigor cross-bridges along a reconstituted thin filament in a skeletal myofibril.Biophysical journal · 2011Article
- The different muscle-energetics during shortening and stretch.International journal of molecular sciences · 2011Review
- Electron tomography of cryofixed, isometrically contracting insect flight muscle reveals novel actin-myosin interactions.PloS one · 2010Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a model study of gliding assays in which actin filaments are moved by nonprocessive myosin motors. We show that even if the power stroke of the motor protein has no lateral component, the filaments will rotate around their axis while moving over the surface. Notably, the handedness of this twirling motion is opposite from that of the actin filament structure. It stems from the fact that the gliding actin filament has target zones, where its subunits point toward the surface and are therefore more accessible for myosin heads. Each myosin head has a higher binding probability before it reaches the center of the target zone than afterwards, which results in a left-handed twirling. We present a stochastic simulation and an approximative analytical solution. The calculated pitch of the twirling motion depends on the filament velocity (ATP concentration). It reaches approximately 400 nm for low speeds and increases with higher speeds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.