ArticleBiophysical journal2009
Statistical analysis of lateral diffusion and multistate kinetics in single-molecule imaging.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Pointwise prediction of protein diffusive properties using machine learning.JPhys photonics · 2025Article
- Application of single-molecule analysis to singularity phenomenon of cells.Biophysics and physicobiology · 2024Article
- A dynamic partitioning mechanism polarizes membrane protein distribution.Nature communications · 2023Article
- Field model for multistate lateral diffusion of various transmembrane proteins observed in living Dictyostelium cells.Journal of cell science · 2023Article
- Maximum likelihood-based estimation of diffusion coefficient is quick and reliable method for analyzing estradiol actions on surface receptor movements.Frontiers in neuroinformatics · 2023Article
- Single-molecule tracking of Nodal and Lefty in live zebrafish embryos supports hindered diffusion model.Nature communications · 2022Article
- Article
- Single-molecule imaging of PI(4,5)PCommunications biology · 2020Article
- Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells.Nature communications · 2018Article
- Automated single-molecule imaging in living cells.Nature communications · 2018Article
- Article
- A Simple and Powerful Analysis of Lateral Subdiffusion Using Single Particle Tracking.Biophysical journal · 2017Article
- Article
- PTEN hopping on the cell membrane is regulated via a positively-charged C2 domain.PLoS computational biology · 2014Article
- TrackArt: the user friendly interface for single molecule tracking data analysis and simulation applied to complex diffusion in mica supported lipid bilayers.BMC research notes · 2014Article
- Intracellular encoding of spatiotemporal guidance cues in a self-organizing signaling system for chemotaxis in Dictyostelium cells.Biophysical journal · 2013Article
- Influences of excluded volume of molecules on signaling processes on the biomembrane.PloS one · 2013Article
- Asymmetric PTEN distribution regulated by spatial heterogeneity in membrane-binding state transitions.PLoS computational biology · 2013Article
- A benchmark for chromatin binding measurements in live cells.Nucleic acids research · 2012Article
- Fluorescent saxitoxins for live cell imaging of single voltage-gated sodium ion channels beyond the optical diffraction limit.Chemistry & biology · 2012Article
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3 authors.
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Abstract
Single-molecule trajectories of molecules on the membrane of living cells have indicated the possibility that the lateral mobility of individual molecules is variable with time. Such temporal variation in mobility may indicate intrinsic kinetics of multiple molecular states. To clarify the mechanisms of signal processing on the membrane, quantitative characterizations of such temporal variations are necessary. Here we propose a method to analyze and characterize the multiple states in lateral mobility and their transition kinetics from single-molecule trajectories based on a displacement probability density function and an autocorrelation function of squared displacements. We performed our method for three cases: a molecule with a single diffusion coefficient (D), a mixture of molecules in two states with different D-values, and a molecule switching between two states with different D-values. Our analysis of numerically generated trajectories successfully distinguished the three cases and estimated the characteristic parameters for mobility and the kinetics of state transitions. This method is applicable to single-molecule tracking analysis of molecules in multiple functional states with different lateral mobility on the membrane of living cells.
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