ArticleBiophysical journal2009
Hybrid lipids as a biological surface-active component.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- Domain Size Regulation in Phospholipid Model Membranes Using Oil Molecules and Hybrid Lipids.The journal of physical chemistry. B · 2022Article
- Partitioning of a Hybrid Lipid in Domains of Saturated and Unsaturated Lipids in a Model Cellular Membrane.ACS omega · 2021Article
- Zwitterionic Character and Lipid Composition Determine the Behaviour of Glycosylphosphatidylinositol Fragments in Monolayers.Chemphyschem : a European journal of chemical physics and physical chemistry · 2021Article
- Cinnamic Acid Derivatives and Their Biological Efficacy.International journal of molecular sciences · 2020Review
- The antioxidant vitamin E as a membrane raft modulator: Tocopherols do not abolish lipid domains.Biochimica et biophysica acta. Biomembranes · 2020Article
- Fluid Phase Coexistence in Biological Membrane: Insights from Local Nonaffine Deformation of Lipids.Biophysical journal · 2018Article
- Phospholipid Chain Interactions with Cholesterol Drive Domain Formation in Lipid Membranes.Biophysical journal · 2018Article
- Composition Fluctuations in Lipid Bilayers.Biophysical journal · 2017Article
- Geodesic curvature driven surface microdomain formation.Journal of computational physics · 2017Article
- Thermal Stability of Phase-Separated Domains in Multicomponent Lipid Membranes with Local Anesthetics.Membranes · 2017Article
- Trace membrane additives affect lipid phases with distinct mechanisms: a modified Ising model.European biophysics journal : EBJ · 2015Article
- Registered and antiregistered phase separation of mixed amphiphilic bilayers.Biophysical journal · 2015Article
- Combined effect of cortical cytoskeleton and transmembrane proteins on domain formation in biomembranes.The Journal of chemical physics · 2014Article
- Modulation of a small two-domain lipid vesicle by linactants.The journal of physical chemistry. B · 2014Article
- The many faces of lipid rafts.Biophysical journal · 2014Article
- Macroscopic phase separation, modulated phases, and microemulsions: a unified picture of rafts.Biophysical journal · 2014Article
- Liquid general anesthetics lower critical temperatures in plasma membrane vesicles.Biophysical journal · 2013Article
- Model of a raft in both leaves of an asymmetric lipid bilayer.Biophysical journal · 2013Article
- Monolayer curvature stabilizes nanoscale raft domains in mixed lipid bilayers.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Formation and domain partitioning of H-ras peptide nanoclusters: effects of peptide concentration and lipid composition.Journal of the American Chemical Society · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell membranes contain small domains (on the order of nanometers in size, sometimes called rafts) of lipids whose hydrocarbon chains are more ordered than those of the surrounding bulk-phase lipids. Whether these domains are fluctuations, metastable, or thermodynamically stable, is still unclear. Here, we show theoretically how a lipid with one saturated hydrocarbon chain that prefers the ordered environment and one partially unsaturated chain that prefers the less ordered phase, can act as a line-active component. We present a unified model that treats the lipids in both the bulk and at the interface and show how they lower the line tension between domains, eventually driving it to zero at sufficiently large interaction strengths or at sufficiently low temperatures. In this limit, finite-sized domains stabilized by the packing of these hybrid lipids can form as equilibrium structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.