ArticleBiophysical journal2009
The elastic properties of the Cryptococcus neoformans capsule.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
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- Neutron Scattering Analysis ofbioRxiv : the preprint server for biology · 2023Article
- Host populations, challenges, and commercialization of cryptococcal vaccines.PLoS pathogens · 2023Article
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- Dexamethasone and Methylprednisolone Promote Cell Proliferation, Capsule Enlargement, andFrontiers in fungal biology · 2021Article
- Ultrastructural Study ofFrontiers in microbiology · 2021Article
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- The capsule ofVirulence · 2019Review
- The mechanical properties of microbial surfaces and biofilms.Cell surface (Amsterdam, Netherlands) · 2019Article
- Genotypic and Phenotypic Diversity ofFrontiers in microbiology · 2018Article
- The environmental yeast Cryptococcus liquefaciens produces capsular and secreted polysaccharides with similar pathogenic properties to those of C. neoformans.Scientific reports · 2017Article
- Influenza A Virus as a Predisposing Factor for Cryptococcosis.Frontiers in cellular and infection microbiology · 2017Article
- Magnesium Ion Acts as a Signal for Capsule Induction in Cryptococcus neoformans.Frontiers in microbiology · 2016Article
- Antiviral, Antifungal and Antibacterial Activities of a BODIPY-Based Photosensitizer.Molecules (Basel, Switzerland) · 2015Article
- Microrheology with optical tweezers: measuring the relative viscosity of solutions 'at a glance'.Scientific reports · 2015Article
- The Cryptococcus neoformans capsule: lessons from the use of optical tweezers and other biophysical tools.Frontiers in microbiology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Microbial capsules are important for virulence, but their architecture and physical properties are poorly understood. The human pathogenic fungus Cryptococcus neoformans has a large polysaccharide capsule that is necessary for virulence and is the target of protective antibody responses. To study the C. neoformans capsule we developed what we believe is a new approach whereby we probed the capsular elastic properties by applying forces using polystyrene beads manipulated with optical tweezers. This method allowed us to determine the Young's modulus for the capsule in various conditions that affect capsule growth. The results indicate that the Young's modulus of the capsule decreases with its size and increases with the Ca(2+) concentration in solution. Also, capsular polysaccharide manifests an unexpected affinity for polystyrene beads, a property that may function in attachment to host cells and environmental structures. Bead probing with optical tweezers provides a new, nondestructive method that may have wide applicability for studying the effects of growth conditions, immune components, and drugs on capsular properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.