ArticleThe European journal of neuroscience2009
Regulation of motor patterns by the central spike-initiation zone of a sensory neuron.
Article in The European journal of neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Interneurons exhibit attenuated ectopic action potential firing in a severe neurodevelopmental disorder.Journal of neurophysiology · 2025Article
- Activity-Dependent Ectopic Spiking in Parvalbumin-Expressing Interneurons of the Neocortex.eNeuro · 2024Article
- Activity-dependent ectopic action potentials in regular-spiking neurons of the neocortex.Frontiers in cellular neuroscience · 2023Article
- Mutual Suppression of Proximal and Distal Axonal Spike Initiation Determines the Output Patterns of a Motor Neuron.Frontiers in cellular neuroscience · 2019Article
- Axonal Conduction Velocity Measurement.Bio-protocol · 2017Article
- The Site of Spontaneous Ectopic Spike Initiation Facilitates Signal Integration in a Sensory Neuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Phase maintenance in a rhythmic motor pattern during temperature changes in vivo.Journal of neurophysiology · 2014Article
- Article
- Optical imaging of neuronal activity and visualization of fine neural structures in non-desheathed nervous systems.PloS one · 2014Article
- Neuropilar projections of the anterior gastric receptor neuron in the stomatogastric ganglion of the Jonah crab, Cancer borealis.PloS one · 2013Article
- Dopamine modulation of Ih improves temporal fidelity of spike propagation in an unmyelinated axon.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The stomatogastric nervous system as a model for studying sensorimotor interactions in real-time closed-loop conditions.Frontiers in computational neuroscience · 2012Article
- Beyond faithful conduction: short-term dynamics, neuromodulation, and long-term regulation of spike propagation in the axon.Progress in neurobiology · 2011Review
- Neural circuit flexibility in a small sensorimotor system.Current opinion in neurobiology · 2011Review
- Cell specific dopamine modulation of the transient potassium current in the pyloric network by the canonical D1 receptor signal transduction cascade.Journal of neurophysiology · 2010Article
- Dopamine modulates Ih in a motor axon.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Modulation of stomatogastric rhythms.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2009Review
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Sensory feedback from muscles and peripheral sensors acts to initiate, tune or reshape motor activity according to the state of the body. Yet, sensory neurons often show low levels of activity even in the absence of sensory input. Here we examine the functional role of spontaneous low-frequency activity of such a sensory neuron. The anterior gastric receptor (AGR) is a muscle-tendon organ in the crab stomatogastric nervous system whose phasic activity shapes the well-characterized gastric mill (chewing) and pyloric (filtering) motor rhythms. Phasic activity is driven by a spike-initiation zone near the innervated muscle. We demonstrate that AGR possesses a second spike-initiation zone, which is located spatially distant from the innervated muscle in a central section of the axon. This initiation zone generates tonic activity and is responsible for the spontaneous activity of AGR in vivo, but does not code sensory information. Rather, it is sensitive to the neuromodulator octopamine. A computational model indicates that the activity at this initiation zone is not caused by excitatory input from another neuron, but generated intrinsically. This tonic activity is functionally relevant, because it modifies the activity state of the gastric mill motor circuit and changes the pyloric rhythm. The sensory function of AGR is not impaired as phasic activity suppresses spiking at the central initiation zone. Our results thus demonstrate that sensory neurons are not mere reporters of sensory signals. Neuromodulators can elicit non-sensory coding activity in these neurons that shapes the state of the motor system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.