ArticleThe European journal of neuroscience2009
Selective activation of dorsal raphe nucleus-projecting neurons in the ventral medial prefrontal cortex by controllable stress.
Article in The European journal of neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
61 citing papers in PubMed, 104 citations in OpenAlex.
- Exercise Myokine Irisin Enables Behavioral Stress Resistance in Mice.bioRxiv : the preprint server for biology · 2026Article
- Sleep and stress as modifiable drivers of Alzheimer's disease.NPJ dementia · 2026Review
- Low affinity noradrenergic signaling promotes passive coping during reinforcement behavior.bioRxiv : the preprint server for biology · 2025Article
- Response of parvalbumin interneurons and perineuronal nets in rat medial prefrontal cortex and lateral amygdala to stressor controllability.Brain research · 2025Article
- Prior experience with behavioral control over stress facilitates social dominance.Neurobiology of stress · 2024Article
- Learned Helplessness As a Potential Transdiagnostic Therapeutic Mechanism of Classic Psychedelics.Psychedelic medicine (New Rochelle, N.Y.) · 2023Review
- From helplessness to controllability: toward a neuroscience of resilience.Frontiers in psychiatry · 2023Review
- Prefrontal cortex and depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Environmental certainty influences the neural systems regulating responses to threat and stress.Neuroscience and biobehavioral reviews · 2021Review
- Cannabidiol and the corticoraphe circuit in post-traumatic stress disorder.IBRO neuroscience reports · 2021Review
- Using social rank as the lens to focus on the neural circuitry driving stress coping styles.Current opinion in neurobiology · 2021Review
- Article
- Functional networks activated by controllable and uncontrollable stress in male and female rats.Neurobiology of stress · 2020Article
- Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions.Molecular psychiatry · 2020Review
- Sex differences in resilience: Experiential factors and their mechanisms.The European journal of neuroscience · 2020Review
- Activity of a vmPFC-DRN Pathway Corresponds With Resistance to Acute Social Defeat Stress.Frontiers in neural circuits · 2020Article
- Voluntary exercise enables stress resistance in females.Behavioural brain research · 2019Article
- Dopamine tunes prefrontal outputs to orchestrate aversive processing.Brain research · 2019Review
- A Focus on the Functions of Area 25.Brain sciences · 2019Review
- Controllable stress elicits circuit-specific patterns of prefrontal plasticity in males, but not females.Brain structure & function · 2019Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Exposure to uncontrollable stressors produces a variety of behavioral consequences (e.g. exaggerated fear, reduced social exploration) that do not occur if the stressor is controllable. In addition, an initial experience with a controllable stressor can block the behavioral and neural responses to a later uncontrollable stressor. The serotonergic (5-HT) dorsal raphe nucleus (DRN) has come to be viewed as a critical structure in mediating the behavioral effects of uncontrollable stress. Recent work suggests that the buffering effects of behavioral control on the DRN-dependent behavioral outcomes of uncontrollable stress require ventral medial prefrontal cortex (mPFCv) activation at the time of behavioral control. The present studies were conducted to directly determine whether or not controllable stress selectively activates DRN-projecting neurons within the mPFCv. To examine this possibility in the rat, we combined retrograde tracing (fluorogold iontophoresed into the DRN) with Fos immunohistochemistry, a marker for neural activation. Exposure to controllable, relative to uncontrollable, stress increased Fos expression in fluorogold-labeled neurons in the prelimbic region (PL) of the mPFCv. Furthermore, in a separate experiment, a prior experience with controllable stress led to potentiation of Fos expression in retrogradely labeled PL neurons in response to an uncontrollable stressor 1 week later. These results suggest that the PL selectively responds to behavioral control and utilizes such information to regulate the brainstem response to ongoing and subsequent stressors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.