ReviewAnnals of the New York Academy of Sciences2009
Parabrachial coding of sapid sucrose: relevance to reward and obesity.
Review in Annals of the New York Academy of Sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Effects of selective adaptation on coding sugar and salt tastes in mixtures.Chemical senses · 2012Trial
- Enhancement of retronasal odors by taste.Chemical senses · 2012Trial
- Central control of gastrointestinal functions in health and disease.Physiological reviews · 2026Review
- Noradrenergic Input from Nucleus of the Solitary Tract Regulates Parabrachial Activity in Mice.eNeuro · 2023Article
- An Amygdalo-Parabrachial Pathway Regulates Pain Perception and Chronic Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The Effects of Amphetamine and Methamphetamine on the Release of Norepinephrine, Dopamine and Acetylcholine From the Brainstem Reticular Formation.Frontiers in neuroanatomy · 2019Article
- Developmental specification of metabolic circuitry.Frontiers in neuroendocrinology · 2015Review
- Cognitive and autonomic determinants of energy homeostasis in obesity.Nature reviews. Endocrinology · 2015Review
- Longitudinal analysis of calorie restriction on rat taste bud morphology and expression of sweet taste modulators.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- The effects of bariatric surgery: will understanding its mechanism render the knife unnecessary?Expert review of gastroenterology & hepatology · 2014Article
- Modulation of taste responsiveness and food preference by obesity and weight loss.Physiology & behavior · 2012Review
- GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake.Endocrinology · 2012Article
- "Liking" and "wanting" of sweet and oily food stimuli as affected by high-fat diet-induced obesity, weight loss, leptin, and genetic predisposition.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Roux-en-Y gastric bypass surgery changes food reward in rats.International journal of obesity (2005) · 2011Article
- Reward and neurocomputational processes.Current topics in behavioral neurosciences · 2011Review
- Gastric bypass surgery alters behavioral and neural taste functions for sweet taste in obese rats.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Chronic sugar intake dampens feeding-related activity of neurons synthesizing a satiety mediator, oxytocin.Peptides · 2010Article
- Parabrachial complex processes dura inputs through a direct trigeminal ganglion-to-parabrachial connection.Neurobiology of pain (Cambridge, Mass.)Article
- Amplified parabrachial nucleus activity in a rat model of trigeminal neuropathic pain.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cumulative evidence in rats suggests that the pontine parabrachial nuclei (PBN) are necessary for assigning hedonic value to taste stimuli. In a series of studies, our laboratory has investigated the parabrachial coding of sapid sucrose in normal and obese rats. First, using chronic microdialysis, we demonstrated that sucrose intake increases dopamine release in the nucleus accumbens, an effect that is dependent on oral stimulation and on concentration. The dopamine response was independent of the thalamocortical gustatory system but was blunted substantially by lesions of the PBN. Similar lesions of the PBN but not the thalamic taste relay diminished cFos activation in the nucleus accumbens caused by sucrose ingestion. Recent single-neuron recording studies have demonstrated that processing of sucrose-evoked activity in the PBN is altered in Otsuka Long Evans Tokushima Fatty (OLETF) rats, which develop obesity due to chronic overeating and express increased avidity to sweet. Compared with lean controls, taste neurons in OLETF rats had reduced overall sensitivity to sucrose and altered concentration responses, with decreased responses to lower concentrations and augmented responses to higher concentrations. The decreased sensitivity to sucrose was specific to NaCl-best neurons that also responded to sucrose, but the concentration effects were carried by the sucrose-specific neurons. Collectively, these findings support the hypothesis that the PBN enables taste stimuli to engage the reward system and, in doing so, influences food intake and body weight regulation. Obesity, in turn, may further alter the gustatory code via forebrain connections to the taste relays or hormonal changes consequent to weight gain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.