ArticleJournal of the American Chemical Society2009
G-quadruplex DNA bound by a synthetic ligand is highly dynamic.
Article in Journal of the American Chemical Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Helical aromatic oligoamide foldamers as selective G-quadruplex ligands.Nucleic acids research · 2025Article
- Structure, Topology, and Stability of Multiple G-quadruplexes in Long Telomeric Overhangs.Journal of molecular biology · 2024Review
- An automated single-molecule FRET platform for high-content, multiwell plate screening of biomolecular conformations and dynamics.Nature communications · 2023Article
- E. coli Rep helicase and RecA recombinase unwind G4 DNA and are important for resistance to G4-stabilizing ligands.Nucleic acids research · 2020Article
- Preferential targeting of i-motifs and G-quadruplexes by small molecules.Chemical science · 2017Article
- A practical guide to studying G-quadruplex structures using single-molecule FRET.Molecular genetics and genomics : MGG · 2017Review
- Single-Molecule Studies of Telomeres and Telomerase.Annual review of biophysics · 2017Review
- A single molecule study of a fluorescently labeled telomestatin derivative and G-quadruplex interactions.Nucleic acids research · 2017Article
- Single-molecule imaging reveals a common mechanism shared by G-quadruplex-resolving helicases.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Small molecule regulated dynamic structural changes of human G-quadruplexes.Chemical science · 2016Article
- Targeting DNA G-quadruplexes with helical small molecules.Chembiochem : a European journal of chemical biology · 2014Article
- Unraveling secrets of telomeres: one molecule at a time.DNA repair · 2014Review
- G-quadruplex conformation and dynamics are determined by loop length and sequence.Nucleic acids research · 2014Article
- G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Article
- Mechanical unfolding of human telomere G-quadruplex DNA probed by integrated fluorescence and magnetic tweezers spectroscopy.Nucleic acids research · 2013Article
- Kinetic partitioning modulates human telomere DNA G-quadruplex structural polymorphism.PloS one · 2013Article
- Replication protein A unfolds G-quadruplex structures with varying degrees of efficiency.The journal of physical chemistry. B · 2012Article
- Single-molecule investigation of G-quadruplex using a nanopore sensor.Methods (San Diego, Calif.) · 2012Review
- A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.Nature chemistry · 2011Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Using single molecule fluorescence resonance energy transfer, we investigated the interaction between a quadruplex-binding ligand and the human telomeric G-quadruplex. The binding of quinolinecarboxamide macrocycle to telomeric DNA was essentially irreversible and selectively induced and favored one quadruplex conformation. The ligand-quadruplex complex displayed intramolecular dynamics including quadruplex folding and unfolding in the absence of ligand association and dissociation. We report that the G-quadruplex can be stabilized without preventing the intrinsic intramolecular dynamics of telomeric DNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.