ArticleNeurochemical research2010
Telomerase deficiency affects normal brain functions in mice.
Article in Neurochemical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Telomerase Depletion Accelerates Ageing of the Zebrafish Brain.Aging cell · 2025Article
- Oral intake of degalactosylated whey protein increases peripheral blood telomere length in young and aged mice.Scientific reports · 2024Article
- TERT mediates the U-shape of glucocorticoids effects in modulation of hippocampal neural stem cells and associated brain function.CNS neuroscience & therapeutics · 2024Article
- Telomerase reverse transcriptase promotes angiogenesis in neonatal rats after hypoxic-ischemic brain damage.PeerJ · 2022Article
- Panic disorder aging characteristics: The role of telomerase reverse transcriptase gene and brain function.Frontiers in aging neuroscience · 2022Article
- Melatonin Reduces Neuroinflammation and Improves Axonal Hypomyelination by Modulating M1/M2 Microglia Polarization via JAK2-STAT3-Telomerase Pathway in Postnatal Rats Exposed to Lipopolysaccharide.Molecular neurobiology · 2021Article
- Cerebroprotein hydrolysate-I protects senescence-induced by D-galactose in PC12 cells and mice.Food science & nutrition · 2021Article
- Article
- Human telomerase reverse transcriptase positively regulates mitophagy by inhibiting the processing and cytoplasmic release of mitochondrial PINK1.Cell death & disease · 2020Article
- Article
- The Emerging Roles for Telomerase in the Central Nervous System.Frontiers in molecular neuroscience · 2018Review
- Telomere length as a potential biomarker of coronary artery disease.The Indian journal of medical research · 2017Review
- Different requirements of functional telomeres in neural stem cells and terminally differentiated neurons.Genes & development · 2017Article
- [The neuroprotective role of exogenous TERT gene in neonatal rats with hypoxic-ischemic brain damage].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Article
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- Reactivation of Tert in the medial prefrontal cortex and hippocampus rescues aggression and depression of Tert(-/-) mice.Translational psychiatry · 2016Article
- A prospective study of leukocyte telomere length and risk of phobic anxiety among women.Psychiatry research · 2015Article
- Genomic integrity and the ageing brain.Nature reviews. Neuroscience · 2015Review
- Relative telomere length is associated with a functional polymorphism in the monoamine oxidase A gene in a South American sample.Journal of genetics · 2015Article
- PBMC telomerase activity, but not leukocyte telomere length, correlates with hippocampal volume in major depression.Psychiatry research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomerase maintains telomere structures and chromosome stability, and it is essential for preserving the characteristics of stem and progenitor cells. In the brain, the hippocampus and the olfactory bulbs are continuously supplied with neural stem and progenitor cells that are required for adult neurogenesis throughout the life. Therefore, we examined whether telomerase plays important roles in maintaining normal brain functions in vivo. Telomerase reverse transcriptase (TERT) expression was observed in the hippocampus, the olfactory bulbs, and the cerebellum, but the telomerase RNA component (TERC) was not detected in hippocampus and olfactory bulbs. Interestingly, TERT-deficient mice exhibited significantly altered anxiety-like behaviors and abnormal olfaction measuring the functions of the hippocampus and the olfactory bulbs, respectively. However, the cerebellum-dependent behavior was not changed in these mutant mice. These results suggest that TERT is constitutively expressed in the hippocampus and the olfactory bulbs, and that it is important for regulating normal brain functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.