ArticleLipids2009
Organ-specific distributions of lysophosphatidylcholine and triacylglycerol in mouse embryo.
Article in Lipids, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 70 citations in OpenAlex.
- Lipid Changes in the Peri-Implantation Period with Mass Spectrometry Imaging: A Systematic Review.Life (Basel, Switzerland) · 2023Review
- Unique Distribution of Diacyl-, Alkylacyl-, and Alkenylacyl-Phosphatidylcholine Species Visualized in Pork Chop Tissues by Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging.Foods (Basel, Switzerland) · 2020Article
- New-generation mass spectrometry expands the toolbox of cell and developmental biology.Genesis (New York, N.Y. : 2000) · 2017Review
- Metabolomic approach for identifying and visualizing molecular tissue markers in tadpoles of Xenopus tropicalis by mass spectrometry imaging.Biology open · 2016Article
- MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice.Laboratory investigation; a journal of technical methods and pathology · 2015Review
- Article
- Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor.Analytical and bioanalytical chemistry · 2014Article
- Analysis of the lipidome of xenografts using MALDI-IMS and UHPLC-ESI-QTOF.Journal of the American Society for Mass Spectrometry · 2014Article
- Lipidomics analysis revealed the phospholipid compositional changes in muscle by chronic exercise and high-fat diet.Scientific reports · 2013Article
- Human breast cancer tissues contain abundant phosphatidylcholine(36∶1) with high stearoyl-CoA desaturase-1 expression.PloS one · 2013Article
- Article
- Article
- MALDI imaging of lipid biochemistry in tissues by mass spectrometry.Chemical reviews · 2011Article
- From whole-body sections down to cellular level, multiscale imaging of phospholipids by MALDI mass spectrometry.Molecular & cellular proteomics : MCP · 2011Article
- Article
- The detection of glycosphingolipids in brain tissue sections by imaging mass spectrometry using gold nanoparticles.Journal of the American Society for Mass Spectrometry · 2010Article
- Imaging mass spectrometry with silver nanoparticles reveals the distribution of fatty acids in mouse retinal sections.Journal of the American Society for Mass Spectrometry · 2010Article
- Developments and applications of mass microscopy.Medical molecular morphology · 2010Review
- Matrix-assisted laser desorption/ionization imaging mass spectrometry.International journal of molecular sciences · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Imaging mass spectrometry (IMS) has been developed as a method for determining and visualizing the distribution of proteins and lipids across sections of dissected tissue. Although lipids play an important role in mammal development, their detailed distributions have not been analyzed by conventional methods. In this study, we tried to determine and visualize lysophosphatidylcholine (LysoPtdCho) and triacylglycerol (TAG) in a mouse embryo by matrix-assisted laser desorption/ionization (MALDI) hybrid quadrupole time-of-flight (TOF) mass spectrometer. Many peaks were detected from a raster scan of the whole embryonic sections. The peaks at m/z 496.33, 524.36, 879.72, 881.74, and 921.74 were identified by MS/MS analyses as [LysoPtdCho (16:0) + H](+), [LysoPtdCho (18:0) + H](+), [TAG (16:0/18:2/18:1) + Na](+), [TAG (16:0/18:1/18:1) + Na](+), and [TAG (16:0/20:3/18:1) + K](+), respectively. The ion images constructed from the peaks revealed that LysoPtdCho were distributed throughout the body and TAGs were distributed around the brown adipose tissue and in the liver at embryo day 17.5. Thus, IMS system based on MALDI hybrid quadrupole TOF MS revealed the distribution of LysoPtdCho and, more importantly, the organ-specific distribution of TAGs in the embryonic stages of mammals for the first time. We can conclude that this technique enables us to analyze the roles of various lipids during embryogenesis and gives insight for lipid research.
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Registered trials
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