ArticleMolecular biology reports2010
Dynamic changes of territories 17 and 18 during EBV-infection of human lymphocytes.
Article in Molecular biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Assessment of the Utility of Gene Positioning Biomarkers in the Stratification of Prostate Cancers.Frontiers in genetics · 2019Article
- The snail Biomphalaria glabrata as a model to interrogate the molecular basis of complex human diseases.PLoS neglected tropical diseases · 2018Article
- Variation in the Untranslated Genome and Susceptibility to Infections.Frontiers in immunology · 2018Review
- Altered bivalent positioning in metaphase I human spermatocytes from Robertsonian translocation carriers.Journal of assisted reproduction and genetics · 2017Article
- Locus-specific gene repositioning in prostate cancer.Molecular biology of the cell · 2016Article
- Spatial Genome Organization and Its Emerging Role as a Potential Diagnosis Tool.Frontiers in genetics · 2016Review
- Cultivation and differentiation change nuclear localization of chromosome centromeres in human mesenchymal stem cells.PloS one · 2015Article
- Differential spatial repositioning of activated genes in Biomphalaria glabrata snails infected with Schistosoma mansoni.PLoS neglected tropical diseases · 2014Article
- Prp22 and spliceosome components regulate chromatin dynamics in germ-line polyploid cells.PloS one · 2013Article
- Non-random organization of the Biomphalaria glabrata genome in interphase Bge cells and the spatial repositioning of activated genes in cells co-cultured with Schistosoma mansoni.International journal for parasitology · 2011Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interphase chromosomes form distinct spatial domains called chromosome territories (CTs). The arrangement of CTs is non-random and correlated with cellular processes such as differentiation. The purpose of this study is to provide some behavior information of CTs during lymphocyte EBV-infection, which is thought to be a general extra-biological model. Three-dimensional fluorescence in situ hybridization (3D-FISH) was performed on human lymphocytes every 24 h over 96 h periods in EBV-infection. Chromosomes 17 and 18 were selected as target territories for similar size and different gene density. The data indicate that the radial position of territories 17 was altered with time, whereas territories 18 showed relative stable localization. The relative CT volume of CTs 18 to 17 also changed with infection. Our study is the first to examine the timely changes of chromatin positioning and folding in EBV-lymphocyte infection. Dynamic changes in position and folding status of target chromosomes reflected an impact of EBV infection on genome stability.
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