ReviewJournal of inherited metabolic disease2009
Mental retardation and inborn errors of metabolism.
Review in Journal of inherited metabolic disease, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 67 citations in OpenAlex.
- Socio-genomics of intellectual disability in African populations: top research-producing countries.Journal of community genetics · 2026Review
- The integration of plasma non-target metabolomics and lipidomics analysis for the discovery of global developmental delay/intellectual disability biomarkers.Frontiers in cellular neuroscience · 2026Article
- Associations between amino acid levels and autism spectrum disorder severity.BMC psychiatry · 2025Article
- Article
- Suppression of exaggerated NMDAR activity by memantine treatment ameliorates neurological and behavioral deficits in aminopeptidase P1-deficient mice.Experimental & molecular medicine · 2022Article
- How paediatricians investigate early developmental impairment in the UK: a qualitative descriptive study.BMC pediatrics · 2022Article
- Review
- Urine Organic Acids as Metabolic Indicators for Global Developmental Delay/Intellectual Disability in Chinese Children.Frontiers in molecular biosciences · 2021Article
- Screening for organic acidurias and aminoacidopathies in high-risk Brazilian patients: Eleven-year experience of a reference center.Genetics and molecular biology · 2019Article
- The role of integrated behavioral health in caring for patients with metabolic disorders.Annals of translational medicine · 2018Article
- Effects of Acerola (Malpighia emarginata DC.) Juice Intake on Brain Energy Metabolism of Mice Fed a Cafeteria Diet.Molecular neurobiology · 2017Article
- Unexplained developmental delay/learning disability: guidelines for best practice protocol for first line assessment and genetic/metabolic/radiological investigations.Irish journal of medical science · 2016Review
- Demographic and Clinical Findings in Pediatric Patients Affected by Organic Acidemia.Iranian journal of child neurology · 2016Article
- The characterization of neuroenergetic effects of chronic L-tyrosine administration in young rats: evidence for striatal susceptibility.Metabolic brain disease · 2015Article
- Evaluation of the In Vivo and In Vitro Effects of Fructose on Respiratory Chain Complexes in Tissues of Young Rats.Disease markers · 2015Article
- Genetic testing in patients with global developmental delay / intellectual disabilities. A review.Clujul medical (1957) · 2015Review
- The analysis of genetic aberrations in children with inherited neurometabolic and neurodevelopmental disorders.BioMed research international · 2014Article
- Effect of acute and chronic administration of L-tyrosine on nerve growth factor levels in rat brain.Neurochemical research · 2013Article
- Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats.Neurotoxicity research · 2013Article
- Animal models of intellectual disability: towards a translational approach.Clinics (Sao Paulo, Brazil) · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In countries where clinical phenylketonuria is detected by newborn screening inborn errors of metabolism are rare causes of isolated mental retardation. There is no international agreement about what type of metabolic tests must be applied in patients with unspecific mental retardation. However, and although infrequent, there are a number of inborn errors of metabolism that can present in this way. Because of the high recurrence risk and the possibility of specific therapies, guidelines need to be developed and adapted to different populations. The application of a universal protocol may result in a low diagnostic performance in individual ethnic populations. Consideration of associated signs (extraneurological manifestations, psychiatric signs, autistic traits, cerebellar dysfunction, epilepsy or dysmorphic traits) greatly improves the diagnostic fulfilment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.