ArticleInternational journal of clinical and experimental medicine2009
Genetic and environmental factors influencing human diseases with telomere dysfunction.
Article in International journal of clinical and experimental medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Fibrotic interstitial lung diseases and air pollution: a systematic literature review.European respiratory review : an official journal of the European Respiratory Society · 2020Pooled it
- Comprehensive mapping of immune perturbations associated with aplastic anemia.Cell biology and toxicology · 2024Article
- A multicentre ambispective observational study into the incidence and clinical management of aplastic anaemia in Spain (IMAS study).Annals of hematology · 2024Observational
- Pesticides and Chemicals as Potential Risk Factors of Aplastic Anemia: A Case-Control Study Among a Pakistani Population.Clinical epidemiology · 2021Article
- Telomerase and telomeres in aging theory and chronographic aging theory (Review).Molecular medicine reports · 2020Review
- Association between Telomere-Related Polymorphisms and the Risk of IPF and COPD as a Precursor Lesion of Lung Cancer: Findings from the Fukuoka Tobacco-Related Lung Disease (FOLD) Registry.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- [Establishment of New Zealand rabbit models of aplastic anemia].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Telomerase expression in amyotrophic lateral sclerosis (ALS) patients.Journal of human genetics · 2014Article
- Acute exacerbation of idiopathic pulmonary fibrosis associated with air pollution exposure.The European respiratory journal · 2014Article
- In silico discrimination of nsSNPs in hTERT gene by means of local DNA sequence context and regularity.Journal of molecular modeling · 2013Article
- The pathogenesis of COPD and IPF: distinct horns of the same devil?Respiratory research · 2012Review
- Pharmaceutical regulation of telomerase and its clinical potential.Journal of cellular and molecular medicine · 2012Review
- Medical genetics and epigenetics of telomerase.Journal of cellular and molecular medicine · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Both genetic and environmental factors have been implicated in the mechanism underlying the pathogenesis of serious and fatal forms of human blood disorder (acquired aplastic anemia, AA) and lung disease (idiopathic pulmonary fibrosis, IPF). We and other researchers have recently shown that naturally occurring mutations in genes encoding the telomere maintenance complex (telomerase) may predispose patients to the development of AA or IPF. Epidemiological data have shown that environmental factors can also cause and/or exacerbate the pathogenesis of these diseases. The exact mechanisms that these germ-line mutations in telomere maintenance genes coupled with environmental insults lead to ineffective hematopoiesis in AA and lung scarring in IPF are not well understood, however. In this article, we provide a summary of evidence for environmental and genetic factors influencing the diseases. These studies provide important insights into the interplay between environmental and genetic factors leading to human diseases with telomere dysfunction.
Indexed as
Identifiers
19684885PMC2719702W1584639974What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.